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Chemosensitivity of human MCF-7 breast cancer cells to diastereoisomeric diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and specific platinum accumulation

Reile, Herta and Bernhardt, Günther and Koch, Marion and Schönenberger, Helmut and Hollstein, Michael and Lux, Franz (1992) Chemosensitivity of human MCF-7 breast cancer cells to diastereoisomeric diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and specific platinum accumulation. Cancer chemotherapy and pharmacology 30 (2), pp. 113-122.

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Abstract

Cisplatin, raceme-diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinu m(II) sulfate (compound I), meso-diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]-platinum(II) sulfate (compound II), and meso-diaqua[1,2-bis(2,6-dichloro-4- hydroxyphenyl)ethylenediamine]platinum(II) sulfate (compound III) were compared with regard to their effect on the MCF-7 breast cancer cell line in vitro. At equimolar ...

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Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1600591PubMed ID
Classification:
NotationType
Breast Neoplasms/drug therapyMESH
Cisplatin/pharmacokineticsMESH
Culture MediaMESH
DNA, Neoplasm/metabolismMESH
Drug Screening Assays, AntitumorMESH
Drug StabilityMESH
HumansMESH
KineticsMESH
Organoplatinum Compounds/pharmacologyMESH
Platinum/pharmacokineticsMESH
StereoisomerismMESH
Time FactorsMESH
Tumor Cells, Cultured/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2009 13:48
Last Modified:13 Mar 2014 18:32
Item ID:4830
Owner Only: item control page

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