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Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. Part II: Biological evaluation-in vitro studies on the P 388 D1 leukemia cell line

Reile, Herta and Müller, Richard and Gust, Ronald and Laske, Reiner and Krischke, Walter and Bernhardt, Günther and Spruss, Thilo and Jennerwein, Margaretha and Engel, Jürgen and Seeber, Siegfried (1990) Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. Part II: Biological evaluation-in vitro studies on the P 388 D1 leukemia cell line. Archiv der Pharmazie 323 (3), pp. 133-140.

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Abstract

Experiments on the P 388 D1 cell line (48 h exposure) demonstrate that [1,2-bis-(fluorophenyl)ethylenediamine]platinum(II) complexes are comparably active on the cell number and 3H-thymidine incorporation, irrespective of the position of the fluorine atom (ortho, meta, or para) and the nature of the "leaving group" (Cl- or H2O). However, the compounds of the R,R/S,S series are more active than ...

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Item Type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
2344259PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Cell Survival/drug effectsMESH
Cisplatin/pharmacologyMESH
Leukemia P388/pathologyMESH
Leukemia, Experimental/pathologyMESH
MiceMESH
Organoplatinum Compounds/pharmacologyMESH
Tumor Cells, Cultured/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2009 13:12
Last Modified:13 Mar 2014 18:32
Item ID:4832
Owner Only: item control page
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