Reile, Herta and Müller, Richard and Gust, Ronald and Laske, Reiner and Krischke, Walter and Bernhardt, Günther and Spruss, Thilo and Jennerwein, Margaretha and Engel, Jürgen and Seeber, Siegfried
Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. Part II: Biological evaluation-in vitro studies on the P 388 D1 leukemia cell line.
Archiv der Pharmazie 323 (3), pp. 133-140.
Experiments on the P 388 D1 cell line (48 h exposure) demonstrate that [1,2-bis-(fluorophenyl)ethylenediamine]platinum(II) complexes are comparably active on the cell number and 3H-thymidine incorporation, irrespective of the position of the fluorine atom (ortho, meta, or para) and the nature of the "leaving group" (Cl- or H2O). However, the compounds of the R,R/S,S series are more active than ...
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