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Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes, III: Evaluation of the mammary tumor inhibiting properties

Reile, Herta and Spruß, Thilo and Müller, Richard and Gust, Ronald and Bernhardt, Günther and Schönenberger, Helmut and Engel, Jürgen (1990) Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes, III: Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 323 (5), pp. 301-306.

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Abstract

Diastereomeric diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) sulfates and nitrates produce a strong inhibition of the hormone-dependent MXT-M 3.2 mammary carcinoma of the B6D2F1 mouse. Besides an interference in the DNA synthesis in analogy to cisplatin a lowering of the estrogen level due to an interference in steroid biosynthesis is suggested as the mode of action. In contrast to ...

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Item Type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2383173PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
Ethylenediamines/chemical synthesisMESH
FemaleMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Mice, Inbred StrainsMESH
Nitrates/chemical synthesisMESH
Organoplatinum Compounds/chemical synthesisMESH
Sulfuric Acids/chemical synthesisMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2009 13:15
Last Modified:13 Mar 2014 18:32
Item ID:4834
Owner Only: item control page
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