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[1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) complexes, compounds for the endocrine therapy of breast cancer - mode of action I: antitumor activity due to the reduction of the endogenous estrogen level

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Bernhardt, Günther and Spruß, Thilo and Beckenlehner, Karin and Koch, Marion and Krauser, Rudolf and Schlemmer, Richard and Gust, Ronald and Schönenberger, Helmut (2004) [1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) complexes, compounds for the endocrine therapy of breast cancer - mode of action I: antitumor activity due to the reduction of the endogenous estrogen level. Archiv der Pharmazie 337 (6), pp. 335-348.

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Abstract

Aqua[meso-1, 2-bis(2, 6-difluoro-3-hydroxyphenyl)ethylenediamine]sulfatoplatinum(II) (meso-3-PtSO(4)) and its racemate (rac-3-PtSO(4)) are highly active on the hormone-sensitive MXT-M-3, 2 breast cancer of the mouse. In vitro, on the MXT(+) cell culture derived from this tumor, however, they are inactive (meso-3-PtSO(4)) or moderately active (rac-3-PtSO(4)) in concentrations corresponding to ...

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Item Type:Article
Date:2004
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
15188223PubMed ID
10.1002/ardp.200300855DOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents, Hormonal/pharmacologyMESH
Apoptosis/drug effectsMESH
Cell Line, TumorMESH
Estrogens/biosynthesisMESH
FemaleMESH
HumansMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Organoplatinum Compounds/pharmacologyMESH
Ovary/drug effectsMESH
StereoisomerismMESH
Structure-Activity RelationshipMESH
Time FactorsMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:14 Jan 2009 13:28
Last Modified:19 Aug 2010 11:14
Item ID:4836
Owner Only: item control page
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