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[meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl) ethylenediamine]dichloroplatinum(II), a compound with a specific activity on hormone-sensitive breast cancers--evidence for a diethylstilbestrol-like mode of action

Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Schönenberger, Helmut (1999) [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl) ethylenediamine]dichloroplatinum(II), a compound with a specific activity on hormone-sensitive breast cancers--evidence for a diethylstilbestrol-like mode of action. Archiv der Pharmazie 332 (2), pp. 59-69.

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Abstract

[meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) (meso-1-PtCl2), an estrogenic and cytotoxic platinum complex, shows activity against ER+ but not against ER- breast cancers in vivo (ER: estrogen receptor; ER+ and ER- indicate the presence or absence of the ER). To clarify whether its estrogenic or its cytotoxic potency or both properties are the cause of this ...

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Item Type:Article
Date:1999
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
10191716PubMed ID
10.1002/(SICI)1521-4184(19993)332:2<59::AID-ARDP59>3.0.CO;2-BDOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents, Hormonal/pharmacologyMESH
Diethylstilbestrol/pharmacologyMESH
FemaleMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Mice, Inbred StrainsMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Organoplatinum Compounds/pharmacologyMESH
OvariectomyMESH
Receptors, Estrogen/physiologyMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:14 Jan 2009 12:59
Last Modified:19 Aug 2010 11:29
Item ID:4838
Owner Only: item control page
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