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Different response of murine and human mammary tumour models to a series of diastereoisomeric [1,2-bis(difluorophenyl) ethylenediamine]dichloroplatinum(II) complexes

Spruß, Thilo and Bernhardt, Günther and Schickaneder, Edith and Schönenberger, Helmut (1991) Different response of murine and human mammary tumour models to a series of diastereoisomeric [1,2-bis(difluorophenyl) ethylenediamine]dichloroplatinum(II) complexes. Journal of cancer research and clinical oncology 117 (5), pp. 435-443.

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Abstract

A series of isomeric [1,2-bis(difluorophenyl) ethylenediamine]dichloroplatinum(II) complexes and cisplatin were tested on the P388 leukemia and on the murine hormone-independent MXT (M3.2) OVEX and the ovarian-hormone-dependent MXT (M3.2) mammary carcinoma for evaluating antineoplastic activity against breast cancer in vivo. Although these results were heterogeneous, a trend to the ...

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Item Type:Article
Date:1991
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1890139PubMed ID
Classification:
NotationType
Adenocarcinoma/drug therapyMESH
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Breast Neoplasms/drug therapyMESH
Cisplatin/pharmacologyMESH
Drug Screening Assays, AntitumorMESH
Ethylenediamines/pharmacologyMESH
FemaleMESH
HumansMESH
Leukemia P388/drug therapyMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Mice, Inbred DBAMESH
Mice, Inbred StrainsMESH
Neoplasm TransplantationMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Organoplatinum Compounds/pharmacologyMESH
StereoisomerismMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2009 15:18
Last Modified:02 Feb 2012 08:34
Item ID:4843
Owner Only: item control page
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