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Antitumour activity of miltefosine alone and after combination with platinum complexes on MXT mouse mammary carcinoma models

Spruß, Thilo and Bernhardt, Günther and Schönenberger, Helmut and Engel, Jürgen (1993) Antitumour activity of miltefosine alone and after combination with platinum complexes on MXT mouse mammary carcinoma models. Journal of cancer research and clinical oncology 119 (3), pp. 142-149.

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Abstract

Miltefosine, an alkylphosphocholine structurally related to alkyllysophospholipids showed highly selective antitumour activity against the hormone-sensitive variant of the s.c. transplantable MXT mouse mammary adenocarcinoma, the ovary-dependent MXT (M3.2), whereas it was inactive against the hormone-insensitive MXT (M3.2) OVEX variant. A dose of 32 mg/kg miltefosine p.o. daily for 5 weeks was ...

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Item Type:Article
Date:1993
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
8418086PubMed ID
Classification:
NotationType
Adenocarcinoma/drug therapyMESH
AnimalsMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Carcinoma/drug therapyMESH
Cisplatin/administration & dosageMESH
Drug ResistanceMESH
Drug Screening Assays, AntitumorMESH
FemaleMESH
Mammary Neoplasms, Animal/drug therapyMESH
MethotrexateMESH
MiceMESH
Mice, Inbred StrainsMESH
Organ SizeMESH
Ovarian Neoplasms/drug therapyMESH
Phosphorylcholine/administration & dosageMESH
Tumor Cells, CulturedMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2009 15:19
Last Modified:13 Mar 2014 18:31
Item ID:4844
Owner Only: item control page
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