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Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes

vom Orde, Hans Dieter and Reile, Herta and Müller, Richard and Gust, Ronald and Bernhardt, Günther and Spruß, Thilo and Schönenberger, Helmut and Burgemeister, Thomas and Mannschreck, Albrecht (1990) Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes. Journal of cancer research and clinical oncology 116 (5), pp. 434-438.

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Abstract

The enantiomeric [1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes were synthesized and tested on the hormone-sensitive human MCF7 breast cancer cell line and on the P388 leukemia of the mouse. They showed a strong and comparable activity on both tumor ...

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Item Type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Retired Professors > Prof.Dr. Mannschreck
Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2229132PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/therapeutic useMESH
Body Weight/drug effectsMESH
Breast Neoplasms/drug therapyMESH
Cisplatin/therapeutic useMESH
HumansMESH
Leukemia P388/drug therapyMESH
MiceMESH
Mice, Inbred DBAMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Organoplatinum Compounds/therapeutic useMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2009 14:06
Last Modified:13 Mar 2014 18:32
Item ID:4846
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