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Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes

vom Orde, Hans Dieter and Reile, Herta and Müller, Richard and Gust, Ronald and Bernhardt, Günther and Spruß, Thilo and Schönenberger, Helmut and Burgemeister, Thomas and Mannschreck, Albrecht (1990) Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes. Journal of cancer research and clinical oncology 116 (5), pp. 434-438.

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Abstract

The enantiomeric [1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes were synthesized and tested on the hormone-sensitive human MCF7 breast cancer cell line and on the P388 leukemia of the mouse. They showed a strong and comparable activity on both tumor models.

Item Type:

Article

Institutions:

Chemistry and Pharmacy > Institut für Organische Chemie > Retired Professors > Prof.Dr. Mannschreck
Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)

Projects:

SFB 234

Identification Number:

Value	Type
2229132	PubMed ID

Classification:

Notation	Type
Animals	MESH
Antineoplastic Agents/therapeutic use	MESH
Body Weight/drug effects	MESH
Breast Neoplasms/drug therapy	MESH
Cisplatin/therapeutic use	MESH
Humans	MESH
Leukemia P388/drug therapy	MESH
Mice	MESH
Mice, Inbred DBA	MESH
Neoplasms, Hormone-Dependent/drug therapy	MESH
Organoplatinum Compounds/therapeutic use	MESH