Startseite UB

Steroid conjugates of dichloro(6-aminomethylnicotinate)platinum(II): effects on DNA, sex hormone binding globulin, the estrogen receptor, and various breast cancer cell lines

Schobert, Rainer and Bernhardt, Günther and Biersack, Bernhard and Bollwein, Susanne and Fallahi, Magid and Grotemeier, Antje and Hammond, Geoffrey L. (2007) Steroid conjugates of dichloro(6-aminomethylnicotinate)platinum(II): effects on DNA, sex hormone binding globulin, the estrogen receptor, and various breast cancer cell lines. ChemMedChem 2 (3), pp. 333-342.

Full text not available from this repository.

at PubMed

at publisher (via DOI)


Abstract

Esters of 6-aminomethylnicotinic acid with various steroidal alcohols were treated with K(2)PtCl(4) to give the N,N-chelated dichloroplatinum(II) complex conjugates 4. Their interaction with plasmid DNA was monitored by electrophoretic mobility measurements. Their affinities towards sex hormone binding globulin (SHBG) and towards the nuclear estrogen receptor ER(alpha) were assessed by ...

plus


Export bibliographical data

Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
17266159PubMed ID
10.1002/cmdc.200600173DOI
Classification:
NotationType
Antineoplastic Agents/chemical synthesisMESH
Binding SitesMESH
Breast Neoplasms/metabolismMESH
Cell Division/drug effectsMESH
Cisplatin/pharmacologyMESH
DNA/metabolismMESH
Estradiol/metabolismMESH
FemaleMESH
HumansMESH
Organoplatinum Compounds/chemical synthesisMESH
Receptors, Estrogen/metabolismMESH
Sex Hormone-Binding Globulin/metabolismMESH
Steroids/chemical synthesisMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Armin Buschauer
Deposited On:14 Jan 2009 14:41
Last Modified:05 Aug 2009 13:48
Item ID:4849
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact