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In vitro activity of immunoconjugates between cisplatin and an anti-CA125 monoclonal antibody on ovarian cancer cell lines

Beck, E. and Hofmann, M. and Bernhardt, Günther and Jäger, W. and Wildt, L. and Lang, N. (1994) In vitro activity of immunoconjugates between cisplatin and an anti-CA125 monoclonal antibody on ovarian cancer cell lines. Cell biophysics 24-25, pp. 163-173.

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Abstract

Cis-diammine dichloro platinum (II) (CDDP), is a highly potent antineoplastic agent that is used in the treatment of ovarian cancer. However, the clinical use of CDDP is restricted by its severe side effects. In order to reduce these side effects and to enhance its therapeutic efficacy, we developed specific immunoconjugates consisting of the murine monoclonal antibody OC125 and CDDP, using ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
7736521PubMed ID
Classification:
NotationType
Antibodies, MonoclonalMESH
Antigen-Antibody ReactionsMESH
CA-125 Antigen/immunologyMESH
Cell Division/drug effectsMESH
Cisplatin/therapeutic useMESH
FemaleMESH
HumansMESH
Immunoconjugates/therapeutic useMESH
Ovarian Neoplasms/therapyMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Jan 2009 15:05
Last Modified:26 Jan 2012 14:07
Item ID:4850
Owner Only: item control page
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