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Picolinic Acids as Inhibitors of Dopamine b-Monooxygenase: QSAR and Putative Binding Site

Dove, Stefan (2004) Picolinic Acids as Inhibitors of Dopamine b-Monooxygenase: QSAR and Putative Binding Site. Archiv der Pharmazie 337 (12), pp. 645-653.

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Other URL: http://www3.interscience.wiley.com/journal/109857450/abstract


Abstract

Dopamine b-monooxygenase (DBM, EC 1.14.17.1) catalyzes the oxidn. of dopamine into (R)-noradrenaline. DBM inhibitors may act as antihypertensive drugs. A series of 22 picolinic acids substituted in 4- and 5-position was previously synthesized and tested for inhibition of DBM from bovine adrenal medulla. The QSAR of these compds. were investigated by Hansch anal. and comparative mol. field ...

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Item Type:Article
Date:2004
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
2005:53484Other
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Stefan Dove
Deposited On:21 Jan 2009 17:45
Last Modified:05 Aug 2009 13:50
Item ID:5403
Owner Only: item control page
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