Dove, Stefan (2004) Picolinic Acids as Inhibitors of Dopamine b-Monooxygenase: QSAR and Putative Binding Site. Archiv der Pharmazie 337 (12), pp. 645-653.
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Dopamine b-monooxygenase (DBM, EC 126.96.36.199) catalyzes the oxidn. of dopamine into (R)-noradrenaline. DBM inhibitors may act as antihypertensive drugs. A series of 22 picolinic acids substituted in 4- and 5-position was previously synthesized and tested for inhibition of DBM from bovine adrenal medulla. The QSAR of these compds. were investigated by Hansch anal. and comparative mol. field ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||21 Jan 2009 17:45|
|Last Modified:||05 Aug 2009 13:50|