Dove, Stefan and Franke, R. (1991) Model-based LFER parameters and QSAR of ligand-ß-adrenoceptor interactions. II. Estimation and QSAR of agonistic potency and receptor affinity in a series of ß-adrenergic phenethanolamines. Quantitative structure activity relationships 10 (1), pp. 23-31.
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Based on an equil. model of ligand-b-adrenoceptor interactions and b-adrenergic effectuation presented in a preceding paper, LFER-related biol. parameters that characterize affinity for the receptor and agonistic potency, resp., are derived for a series of 44 phenethanolamines from measured apparent dissocn. consts. KL, and intrinsic activities aAC for adenylate cyclase activation. Hansch ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Dewey Decimal Classification:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Deposited on:||21 Jan 2009 17:07|
|Last modified:||05 Aug 2009 13:50|