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Model-based LFER parameters and QSAR of ligand-ß-adrenoceptor interactions. II. Estimation and QSAR of agonistic potency and receptor affinity in a series of ß-adrenergic phenethanolamines

Dove, Stefan and Franke, R. (1991) Model-based LFER parameters and QSAR of ligand-ß-adrenoceptor interactions. II. Estimation and QSAR of agonistic potency and receptor affinity in a series of ß-adrenergic phenethanolamines. Quantitative structure activity relationships 10 (1), pp. 23-31.

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Other URL: http://www3.interscience.wiley.com/journal/113323309/abstract


Abstract

Based on an equil. model of ligand-b-adrenoceptor interactions and b-adrenergic effectuation presented in a preceding paper, LFER-related biol. parameters that characterize affinity for the receptor and agonistic potency, resp., are derived for a series of 44 phenethanolamines from measured apparent dissocn. consts. KL, and intrinsic activities aAC for adenylate cyclase activation. Hansch ...

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Item Type:Article
Date:1991
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1991:464032Other
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Prof. Dr. Stefan Dove
Deposited On:21 Jan 2009 17:07
Last Modified:05 Aug 2009 13:50
Item ID:5415
Owner Only: item control page
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