Dove, Stefan and Franke, R. (1991) Activity data decomposition - levels, methods and principles. In: Silipo, C., (ed.) QSAR: Rational approaches in the design of bioactive compounds. Pharmacochemistry library, 16. Elsevier, Amsterdam, 37 - 40. ISBN 0-444-88839-X.
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Anal. and decompn. of biol. activity data are prerequisites to more informative QSAR results. It is often valuable to decomp. activity data of higher into such of lower complexity in order to better investigate the mechanisms of action. Three levels are discussed and illustrated with examples: systemic activity data decompn., relations of data measured in vivo and in vitro, and receptor/enzyme binding data decompn.
|Item Type:||Book Section|
|Additional information (public):||Proceedings of the VIII European Symposium on Quantitative Structure-Activity Relationships, Sorrento, Italy, 9 - 13 September 1990|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
|Refereed:||No, this version has not been refereed yet (as with preprints)|
|Created at the University of Regensburg:||No|
|Owner:||Prof. Dr. Stefan Dove|
|Deposited On:||21 Jan 2009 16:40|
|Last Modified:||05 Aug 2009 13:50|