Activity data decomposition - levels, methods and principles

Abstract

Anal. and decompn. of biol. activity data are prerequisites to more informative QSAR results. It is often valuable to decomp. activity data of higher into such of lower complexity in order to better investigate the mechanisms of action. Three levels are discussed and illustrated with examples: systemic activity data decompn., relations of data measured in vivo and in vitro, and receptor/enzyme binding data decompn.