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Discriminant-Analytical Investigation on the Structural Dependence of Hyperglycemic and Hypoglycemic Activity in a Series of Substituted ortho-Toluolsulphonylthioureas and ortho-Toluolsulphonylureas

Dove, Stefan and Franke, R. and Mndshojan, O. L. and Shkuljev, W. A. and Chashakjan, L. W. (1979) Discriminant-Analytical Investigation on the Structural Dependence of Hyperglycemic and Hypoglycemic Activity in a Series of Substituted ortho-Toluolsulphonylthioureas and ortho-Toluolsulphonylureas. Journal of Medicinal Chemistry 22 (1), pp. 90-95.

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Other URL: http://pubs.acs.org/doi/abs/10.1021/jm00187a020


Abstract

Twenty-two substituted title compds.(I and II) (R = Me, OMe, OEt, NHAc, etc.; R1 = H, Me, Et, Pr, Bu, and CH2Ph; X = O or S) were synthesized and tested for their hyper- and hypoglycemic activities in rats. The data were evaluated using discriminant anal. The hydrophobic and (or) steric properties as well as the presence or absence of the thioamide group were the most important variables. ...

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Item Type:Article
Date:1979
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1979:66505Other
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Prof. Dr. Stefan Dove
Deposited On:21 Jan 2009 16:48
Last Modified:05 Aug 2009 13:50
Item ID:5419
Owner Only: item control page
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