Dove, Stefan and Franke, R. and Mndshojan, O. L. and Shkuljev, W. A. and Chashakjan, L. W. (1979) Discriminant-Analytical Investigation on the Structural Dependence of Hyperglycemic and Hypoglycemic Activity in a Series of Substituted ortho-Toluolsulphonylthioureas and ortho-Toluolsulphonylureas. Journal of Medicinal Chemistry 22 (1), pp. 90-95.
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Twenty-two substituted title compds.(I and II) (R = Me, OMe, OEt, NHAc, etc.; R1 = H, Me, Et, Pr, Bu, and CH2Ph; X = O or S) were synthesized and tested for their hyper- and hypoglycemic activities in rats. The data were evaluated using discriminant anal. The hydrophobic and (or) steric properties as well as the presence or absence of the thioamide group were the most important variables. Apparently, 2 different mechanisms of action with opposite effect are involved in the compds. studied.
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Deposited On:||21 Jan 2009 16:48|
|Last Modified:||05 Aug 2009 13:50|