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Discriminant-Analytical Investigation on the Structural Dependence of Hyperglycemic and Hypoglycemic Activity in a Series of Substituted ortho-Toluolsulphonylthioureas and ortho-Toluolsulphonylureas

Dove, Stefan ; Franke, R. ; Mndshojan, O. L. ; Shkuljev, W. A. ; Chashakjan, L. W.



Zusammenfassung

Twenty-two substituted title compds.(I and II) (R = Me, OMe, OEt, NHAc, etc.; R1 = H, Me, Et, Pr, Bu, and CH2Ph; X = O or S) were synthesized and tested for their hyper- and hypoglycemic activities in rats. The data were evaluated using discriminant anal. The hydrophobic and (or) steric properties as well as the presence or absence of the thioamide group were the most important variables. Apparently, 2 different mechanisms of action with opposite effect are involved in the compds. studied.


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