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Computer modelling of estrogenic transcriptional activation can account for different types of dose-response curves of estrogens

Dove, Stefan and Schönenberger, Helmut (1993) Computer modelling of estrogenic transcriptional activation can account for different types of dose-response curves of estrogens. The Journal of Steroid Biochemistry and Molecular Biology 46 (2), pp. 163-176.

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Other URL: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8X-47PR4YP-16N&_user=616165&_coverDate=08%2F31%2F1993&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000032338&_version=1&_urlVersion=0&_userid=616165&md5=0776cb26d56c6368683cf3172fd76b4b


Abstract

Estrogenic activity of diphenylethanes and -ethenes was detd. by uterine growth in immature mice and analyzed by weighed regression of logit-transformed effect on log dose values. This resulted in a range of Hill coeffs. nH from 0.3 to 2 corresponding to the mol. mechanism of estrogenic transcriptional activation. Binding of agonists (hormones, H) to estrogen receptors (ER) leads to receptor ...

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Item Type:Article
Date:1993
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1993:617624Other
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Stefan Dove
Deposited On:21 Jan 2009 16:23
Last Modified:19 Aug 2010 12:00
Item ID:5426
Owner Only: item control page
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