Dove, Stefan and Streich, J. and Franke, R. (1980) On the Rational Selection of Test Series. II. Two-Dimensional Mapping of Intraclass Correlation Matrices (TMIC Method). Journal of Medicinal Chemistry 23 (12), pp. 1456-1459.
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A 2-dimensional mapping of intraclass correlation matrixes (TMIC) as a tool in drug design is presented. The variance coeff. obtained with TMIC is somewhat smaller than the corresponding values from multidimensional mapping, however, the differences are marginal. TMIC is a simple and comprehensive method for the selection of optimal test series if the no. of compds. in the starting population is <50.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 510 Mathematics|
500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Owner:||Prof. Dr. Stefan Dove|
|Deposited On:||21 Jan 2009 16:21|
|Last Modified:||05 Aug 2009 13:50|