Franke, R. and Barth, A. and Dove, Stefan and Laass, W. (1980) Quantitative Structure-Activity Relationships (QSAR) in Piperidinoacetanilides for Different Biological Effects - Some General Aspects. Pharmazie 35 (3), pp. 181-184.
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The title study was carried out on I (R = H, halo, Me, CF3, NO2, OMe, and OEt) and included growth inhibition of Sinapis alba seedlings and hypocotyl, Triticum aleurone amylase response, as well as anthelmintic, fungistatic and bacteriostatic activity, and inhibition of ribosomal protein synthesis. Math models for the calcn. of pI50 values (Barth, A., et al., 1977) based on hydrophobic, electronic, and steric substituent consts. are given. Varimax rotation factor patterns resulting from test data are tabulated. The importance of complete parameter spaces and of multivariant anal. of multiple biol. data, are discussed.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Owner:||Prof. Dr. Stefan Dove|
|Deposited On:||21 Jan 2009 16:18|
|Last Modified:||05 Aug 2009 13:50|