Hydrophobicity and Hydrophobic Interactions I. On the Physical Nature of Aromatic Hydrophobic Substituent Constants

Abstract

Arom. p-values for 14 meta and para-substituents measured in 8 arom. std. series are analyzed by principal component anal. To reproduce the data within exptl. error, the meta substituents require 2 components, the 1st component reflecting the intrinsic arom. hydrophobicity and the 2nd reflecting electronic correction of the functional groups. Para substituents require 3 components. For both meta and para substituents the 2nd component may be identified with the Hammett const. s. General equations are formulated which describe arom. p-values in terms of intrinsic arom. hydrophobicity and electronic substituent consts.