Franke, R. and Dove, Stefan and Kühne, R. (1979) Hydrophobicity and Hydrophobic Interactions I. On the Physical Nature of Aromatic Hydrophobic Substituent Constants. European journal of medicinal chemistry 14 (4), pp. 363-372.
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Arom. p-values for 14 meta and para-substituents measured in 8 arom. std. series are analyzed by principal component anal. To reproduce the data within exptl. error, the meta substituents require 2 components, the 1st component reflecting the intrinsic arom. hydrophobicity and the 2nd reflecting electronic correction of the functional groups. Para substituents require 3 components. For both meta and para substituents the 2nd component may be identified with the Hammett const. s. General equations are formulated which describe arom. p-values in terms of intrinsic arom. hydrophobicity and electronic substituent consts.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Owner:||Prof. Dr. Stefan Dove|
|Deposited On:||20 Jan 2009 18:16|
|Last Modified:||05 Aug 2009 13:50|