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Drug Design. Dependence of hydrophobicity on solvent and structure

Franke, R. and Kühne, R. and Dove, Stefan (1983) Drug Design. Dependence of hydrophobicity on solvent and structure. In: Dearden, John C., (ed.) Quantitative Approaches to Drug Design. Pharmacochemistry library, 6. Elsevier, Amsterdam, 15 - 32. ISBN 0-444-42200-5.

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Thermodn. solvation/desolvation and hydration data of normal and branched aliph. compds. with a variety of polar groups can be adequately described by cavity surface areas if an extended group contribution concept is applied. The results are contradictory to classical views on hydrophobicity. Partition coeffs. in different solvent-water partitioning systems are shown by a principal component ...


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Item Type:Book Section
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
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Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:No, this document will not be refereed
Created at the University of Regensburg:No
Deposited On:20 Jan 2009 17:57
Last Modified:05 Aug 2009 13:50
Item ID:5433
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