Franke, R. and Vasilev, G. N. and Dove, Stefan (1979) Relationships between Structure and Cytotoxicity of Thiourea Derivatives. Doklady Bolgarskoj Akademii Nauk (Sofia) 32 (3), pp. 369-375.
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The relations between the chem structure of the title compds. (I; R1 = Cl, OH, Me, NHAc, OMe; R2 = H, Cl, Me, OMe, NO2; R3 = alkyl or Ph; n = 1 or 2) and their cytotoxicity were studied by the technique of discriminant anal. To est. the effects of substituents in the substituted Ph ring on cytotoxicity, the hydrophobic substituent const., the Hammett const., and Taft's steric const. were used. The cytotoxicity depended on the hydrophobicity of the substituted Ph ring, on the size of the substituents in the para position, and on the nature of R3.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Owner:||Prof. Dr. Stefan Dove|
|Deposited On:||20 Jan 2009 16:53|
|Last Modified:||05 Aug 2009 13:50|