Mahboobi, Siavosh and Teller, S. and Pongratz, H. and Hufsky, H. and Sellmer, A. and Botzki, Alexander and Uecker, A. and Beckers, T. and Baasner, S. and Schächtele, C. and Überall, F. and Kassack, M. U. and Dove, Stefan and Böhmer, F.-D. (2002) Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. Journal of Medicinal Chemistry 45 (5), pp. 1002-1018.
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The novel lead bis(1H-2-indolyl)methanone inhibits autophosphorylation of platelet-derived growth factor (PDGF) receptor tyrosine kinase in intact cells. Various substituents in the 5- or 6-position of one indole ring increase or preserve potency, whereas most modifications of the ring structures and of the methanone group as well as substitution at both indoles result in weak or no activity. ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
|Projects:||Deutsche Krebshilfe 10-2100|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Partially|
|Owner:||Prof. Dr. Stefan Dove|
|Deposited On:||20 Jan 2009 16:41|
|Last Modified:||05 Aug 2009 13:50|