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4,6-Di(heteroaryl)-2-(N-methylpiperazino)pyrimidines as New, Potent 5-HT2A Receptor Ligands: A Verification of the Topographic Model

Mokrosz, M.J. and Strekowski, L. and Kosak, W.X. and Duszynska, B. and Bojarski, A.J. and Klodzinska, A. and Czarny, A. and Cegla, M.T. and Deren-Wesolek, A. and Chojnacka-Wojcik, E. and Dove, Stefan and Mokrosz, J.L. (1995) 4,6-Di(heteroaryl)-2-(N-methylpiperazino)pyrimidines as New, Potent 5-HT2A Receptor Ligands: A Verification of the Topographic Model. Archiv der Pharmazie 328 (9), pp. 659-666.

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Other URL: http://www3.interscience.wiley.com/journal/113348924/abstract


Abstract

A series of new 4,6-di(heteroaryl)pyrimidines containing an N-methylpiperazino group (6-13) or an ethylenediamine chain (15-20) in position 2 were synthesized and their 5-HT1A and 5-HT2A receptor affinities were determined. It was shown that the substituent effects on the 5-HT2A affinity are additive and could be described quantitatively. In a behavioral model it was also demonstrated that 6-11 ...

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Item Type:Article
Date:1995
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Dr. Stefan Dove
Deposited On:20 Jan 2009 15:55
Last Modified:05 Aug 2009 13:50
Item ID:5453
Owner Only: item control page
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