Radons, Jürgen and Dove, Stefan and Neumann, D. and Altmann, R. and Botzki, Alexander and Martin, M.U. and Falk, Werner (2003) The IL-1 receptor accessory protein TIR domain: analysis of putative interaction sites by in-vitro mutagenesis and molecular modeling. The Journal of Biological Chemistry 278 (49), pp. 49145-49153.
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The Toll/interleukin 1 (IL-1) receptor family plays an important role in both innate and adaptive immunity. These receptors are characterized by a C-terminal homol. motif called the Toll/IL-1 receptor (TIR) domain. A principal function of the TIR domain is mediating homotypic protein-protein interactions in the signal transduction pathway. To suggest interaction sites of TIR domains in the ...
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|Institutions:||Medicine > Lehrstuhl für Innere Medizin I|
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
|Subjects:||500 Science > 570 Life sciences|
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Owner:||Prof. Dr. Stefan Dove|
|Deposited On:||20 Jan 2009 15:40|
|Last Modified:||05 Aug 2009 13:50|