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Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol

Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.

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Abstract

K[PtCl3(NH3)] reacts with an equimolar amt. of 3-(2-amino-ethoxy)estrone (an) or -estradiol (ad) to give cis-[PtCl2(NH3)L] (L = an, ad). The reaction of cis-PtCl2(NH3)2 with the amino L leads to cis-[PtCl(NH3)2L]Cl (I). I (L = ad) is active against the hormone sensitive human breast cancer cell line MCF-7 and L 1210 of the ...

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Item Type:Article
Date:1991
Additional information (public):CAN 115:196743 78-7 Inorganic Chemicals and Reactions 136392-25-1P Role: SPN (Synthetic preparation), FORM (Formation, nonpreparative), PREP (Preparation) (formation of, in prepn. of mono- and diammine analogs); 136392-21-7P; 136392-22-8P; 136392-23-9P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 136392-24-0P; 136458-88-3P; 136521-64-7P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1991:596743Other
10.1021/ic00021a022DOI
Keywords:Neoplasm inhibitors (platinum ammine chloro complexes with aminoethoxyestrone or -estradiol as); antitumor activity platinum chloro aminoethoxyestrone aminoethoxyestradiol; estrone aminoethoxy platinum chloro; estradiol aminoethoxy platinum chloro
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Jan 2009 16:27
Last Modified:13 Mar 2014 18:32
Item ID:5470
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