Deutsch
Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.
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Abstract
K[PtCl3(NH3)] reacts with an equimolar amt. of 3-(2-amino-ethoxy)estrone (an) or -estradiol (ad) to give cis-[PtCl2(NH3)L] (L = an, ad). The reaction of cis-PtCl2(NH3)2 with the amino L leads to cis-[PtCl(NH3)2L]Cl (I). I (L = ad) is active against the hormone sensitive human breast cancer cell line MCF-7 and L 1210 of the mouse.
| Item Type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Additional information (public): | CAN 115:196743 78-7 Inorganic Chemicals and Reactions 136392-25-1P Role: SPN (Synthetic preparation), FORM (Formation, nonpreparative), PREP (Preparation) (formation of, in prepn. of mono- and diammine analogs); 136392-21-7P; 136392-22-8P; 136392-23-9P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 136392-24-0P; 136458-88-3P; 136521-64-7P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of) | ||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||||
| Identification Number: |
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| Keywords: | Neoplasm inhibitors (platinum ammine chloro complexes with aminoethoxyestrone or -estradiol as); antitumor activity platinum chloro aminoethoxyestrone aminoethoxyestradiol; estrone aminoethoxy platinum chloro; estradiol aminoethoxy platinum chloro | ||||||
| Subjects: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Partially | ||||||
| Owner: | Universitätsbibliothek Regensburg | ||||||
| Deposited On: | 15 Jan 2009 17:27 | ||||||
| Last Modified: | 02 Feb 2012 09:26 | ||||||
| Item ID: | 5470 |
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