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Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

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Abstract

The invention relates to the prepn. of novel, water-sol. porphyrin platinum compds. of the tetraarylporphyrin platinum type or of the hematoporphyrin platinum type in which a platinum diamine is bonded to pendant arm/arms of the porphyrin. with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases. These compds. have high tumor selectivity and are proposed ...

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Item Type:Patent
Date:2003
Additional information (public):CAN 139:159041 78-7 Inorganic Chemicals and Reactions Patent 20030807 160734-53-2P; 434933-86-5P; 434933-97-8P; 438583-76-7P; 438583-80-3P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. of water-sol. platinum porphyrin amine complexes with high tumor selectivity for use in photodynamic therapy); 434933-87-6P; 434933-89-8P; 434933-90-1P; 434933-93-4P; 434933-94-5P; 434933-95-6P; 434933-96-7P; 434933-98-9P; 434933-99-0P; 434934-00-6P; 434934-01-7P; 434934-02-8P; 434934-04-0P; 434934-05-1P; 434934-06-2P; 438583-42-7P; 438583-44-9P; 438583-46-1P; 438583-48-3P; 438583-52-9P; 438583-54-1P; 438583-56-3P; 438583-59-6P; 438583-62-1P; 438583-64-3P; 438583-66-5P; 438583-68-7P; 438583-70-1P; 438583-72-3P; 438583-74-5P; 438583-78-9P; 438583-82-5P; 438583-84-7P; 438583-86-9P; 438583-88-1P; 438583-90-5P; 438583-92-7P; 438583-94-9P; 438583-96-1P; 438583-98-3P; 438584-00-0P; 438584-02-2P; 438584-04-4P; 438584-06-6P; 438584-08-8P; 438584-10-2P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (reactant for prepn. of water-sol. platinum porphyrin amine complexes with high tumor selectivity for use in photodynamic therapy); 13965-31-6 ((2,2'-Bipyridine)dichloroplatinum); 38780-40-4 (Dichloro(trans-1,2-diaminocyclohexane)platinum); 149020-66-6; 161096-40-8; 434933-82-1; 434933-83-2; 438245-16-0 Role: RCT (Reactant), RACT (Reactant or reagent) (reactant for prepn. of water-sol. platinum porphyrin amine complexes with high tumor selectivity for use in photodynamic therapy) A2 US 2002-353585 20020201
Institutions:Chemistry and Pharmacy > Institut für Anorganische Chemie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
2003:610452Other
2003-EP8742003064424Other
Keywords:Porphyrins; Role: PAC (Pharmacological activity), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (platinum complexes prepn. of water-sol. platinum porphyrin amine complexes with high tumor selectivity for use in photodynamic therapy); Antitumor agents; Bladder; Photodynamic therapy; Photosensitizers; Phototoxicity (prepn. of water-sol. platinum porphyrin amine complexes with high tumor selectivity for use in photodynamic therapy); platinum porphyrin amine prepn antitumor photodynamic therapy; hematoporphyrin platinum amine prepn antitumor photodynamic therapy
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Guenther Bernhardt
Deposited On:15 Jan 2009 15:47
Last Modified:05 Aug 2009 13:50
Item ID:5471
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