Startseite UB

Carboplatin derivatives with superior antitumor activity compared to the parent compound

Bernhardt, Günther and Brunner, Henri and Gruber, Nick and Lottner, Christian and Pushpan, Simi K. and Tsuno, Takashi and Zabel, Manfred (2004) Carboplatin derivatives with superior antitumor activity compared to the parent compound. Inorganica Chimica Acta 357 (15), pp. 4452-4466.

Full text not available from this repository.


Abstract

A series of new carboplatin derivs. was synthesized by introducing fluoro, chloro, bromo and hydroxy substituents into the cyclobutane ring. The carboxylic acid groups were used for the complexation with platinum(II) fragments bearing two ammonia and (RR/SS)-trans-1,2-diaminocyclohexane ligands, resp., as non-leaving groups. The antiproliferative activity of the new carboplatin analogs differing ...

plus


Export bibliographical data



Item Type:Article
Date:2004
Additional information (public):CAN 142:126560 1-3 Pharmacology 792912-73-3P; 792912-74-4P; 792912-75-5P; 792912-77-7P; 827325-34-8P; 827325-35-9P; 827325-36-0P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (carboplatin derivs. with superior antitumor activity compared to the parent compd.); 99038-34-3 Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (carboplatin derivs. with superior antitumor activity compared to the parent compd.); 5445-51-2 (1,1-Cyclobutanedicarboxylic acid); 15663-27-1 (Cisplatin); 38780-40-4; 41575-94-4; 52241-26-6; 99173-61-2; 123812-76-0; 123812-77-1; 161096-40-8; 792912-76-6 Role: RCT (Reactant), RACT (Reactant or reagent) (carboplatin derivs. with superior antitumor activity compared to the parent compd.); 35995-55-2P; 51816-01-4P (1,1-Cyclobutanedicarbonyl dichloride); 54166-15-3P; 89582-02-5P; 89639-43-0P; 99974-66-0P; 825620-41-5P; 827032-76-8P; 827032-77-9P; 827032-78-0P; 827032-79-1P; 827032-80-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (carboplatin derivs. with superior antitumor activity compared to the parent compd.)
Institutions:Chemistry and Pharmacy > Institut für Anorganische Chemie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
2004:1010893Other
Keywords:Antitumor agents; Bladder; Human; Structure-activity relationship (carboplatin derivs. with superior antitumor activity compared to the parent compd.); Ovary, neoplasm (cisplatin-resistant, carboplatin derivs. with superior antitumor activity compared to the parent compd.); carboplatin deriv prepn
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Guenther Bernhardt
Deposited On:15 Jan 2009 15:49
Last Modified:05 Aug 2009 13:50
Item ID:5472
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact