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The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

Full text not available from this repository.

Abstract

Sensitivity of 5 human melanoma cell lines towards melphalan (L-PAM), dacarbazine (DIC), methotrexate (MTX), vinblastine (VBL), dactinomycin (DACT), doxorubicin (ADM), mitoxantrone (DHAQ), cisplatin (cDDP), and carboplatin (CDBCA) was tested by a standardized kinetic microassay. With respect to achievable plasma concns. in hyperthermic isolated limb perfusion VBL, DHAQ, ADM, DACT, and cDDP seem promising for further pharmacokinetically controlled in vivo-studies.

Item Type:

Article

Additional information (public):

CAN 121:195091 1-6 Pharmacology 50-76-0 (Dactinomycin); 59-05-2 (Methotrexate); 148-82-3 (Melphalan); 865-21-4 (Vinblastine); 4342-03-4 (Dacarbazine); 15663-27-1 (Cisplatin); 23214-92-8 (Doxorubicin); 41575-94-4 (Carboplatin); 65271-80-9 (Mitoxantrone) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Medicine > Lehrstuhl für Chirurgie

Identification Number:

Value	Type
1994:595091	Other

Keywords:

Fever and Hyperthermia (chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion); Neoplasm inhibitors (melanoma, chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion); chemosensitivity human melanoma cell cytostatic; hyperthermic limb perfusion cytostatic chemosensitivity

Subjects:

500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Guenther Bernhardt

Deposited On:

15 Jan 2009 16:43