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Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

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Abstract

Ex vivo expts. with vital brain tumor samples show that hyaluronidase enhances the permeation of carboplatin into tumor tissue with a matrix rich in hyaluronic acid. We achieved long-lasting second remissions for children with relapsed malignant brain tumors treated with carboplatin, etoposide and this enzyme. Thereafter, we initiated a pilot study where we added hyaluronidase to the first line ...

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Item Type:Article
Date:1998
Additional information (public):CAN 130:104864 1-6 Pharmacology 37326-33-3 (Hyaluronidase) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1998:691286Other
Keywords:Antitumor agents (brain hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); Development (child, hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); Brain, neoplasms (hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); Brain, neoplasms (inhibitors, hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); child brain tumor chemotherapy hyaluronidase combination
Subjects:500 Science > 500 Natural sciences & mathematics
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Guenther Bernhardt
Deposited On:15 Jan 2009 15:40
Last Modified:05 Aug 2009 13:50
Item ID:5484
Owner Only: item control page
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