Wimber, Maria and Bäuml, Karl-Heinz and Bergström, Zara and Markopoulos, Gerasimos and Heinze, Hans-Jochen and Richardson-Klavehn, Alan (2008) Neural markers of inhibition in human memory retrieval. The Journal of Neuroscience 28 (50), pp. 13419-13427.
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Retrieving particular information from memory facilitates the later retrieval of that information, but also impairs the later retrieval of related, interfering information. It has been theorized that this retrieval-induced forgetting reflects inhibition of interfering memory representations. We used event-related fMRI to investigate the functional neuroanatomy of this impaired retrieval, at the time the impairment is observed. Neural activity differences between impaired and facilitated information occurred in left ventrolateral prefrontal cortex (VLPFC, BA 45 and 47), precuneus (BA 7), and right inferior parietal lobule (IPL, BA 40). Activity in left anterior VLPFC (BA 47) and left posterior temporal cortex (BA 22), regions implicated in the controlled retrieval of weak semantic memory representations, predicted the degree of retrieval-induced forgetting. In contrast, activity in precuneus and right IPL predicted the degree of retrieval-induced facilitation. Our findings demonstrate that impairment of interfering memories and facilitation of practiced memories involve
distinct neural processes, and suggest that the impairment reflects inhibition that weakens interfering memory representations.
|Institutions:||Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie IV (Entwicklungs- und Kognitionspsychologie) - Prof. Dr. Karl-Heinz Bäuml|
|Subjects:||100 Philosophy & psychology > 150 Psychology|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Partially|
|Deposited On:||14 Jan 2009 17:16|
|Last Modified:||05 Aug 2009 15:50|
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