Mengel, A. and Reiser, O. and Aube, J. (2008) Synthesis and structural study of cyclic 5-aminovaleric acid-linked beta-Ala-beta-Ala dipeptides. Bioorganic & Medicinal Chemistry Letters 18 (22), pp. 5975-5977.
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5-Aminovaleric acid and ornithine were evaluated as linkers for the cyclization of beta-dipeptides. Two linked examples of beta-Ala-beta-Ala were prepared by standard coupling methods and their conformations probed by NMR, CD, and computational means. The data suggest that these non- or monosubstituted versions of the target compounds are flexible in solution.
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|Additional information (public):||Mengel, Anne; Reiser, Oliver; Aube, Jeffrey|
|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Partially|
|Deposited On:||09 Feb 2009 10:37|
|Last Modified:||16 Nov 2009 14:38|