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Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence

Noth, J. and Frankowski, K. J. and Neuenswander, B. and Aube, J. and Reiser, O. (2008) Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence. Journal of Combinatorial Chemistry 10 (3), pp. 456-459.

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A three-component method for the synthesis of highly substituted gamma-lactams from readily available maleimides, aldehydes, and amines is described. A new reductive amination/intramolecular lactamization sequence provides a straightforward route to the lactam products in a single manipulation. The general utility of this method is demonstrated by the parallel synthesis of a gamma-lactam library.

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Item type:Article
Additional Information (public):Noeth, Julica; Frankowski, Kevin J.; Neuenswander, Benjamin; Aube, Jeffrey; Reiser, Oliver
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Identification Number:
ISI:000255848700019Web of Science ID
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Deposited on:09 Feb 2009 09:58
Last modified:16 Nov 2009 14:37
Item ID:5715
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