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Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists

Igel, Patrick and Geyer, Roland and Straßer, Andrea and Dove, Stefan and Seifert, Roland and Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), pp. 6297-6313.

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Other URL: http://pubs.acs.org/doi/full/10.1021/jm900526h?prevSearch=Buschauer&searchHistoryKey=, http://pubs.acs.org/doi/pdf/10.1021/jm900526h, http://www.ncbi.nlm.nih.gov/pubmed/19791743?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


Abstract

Recently, we identified high-affinity human histamine H3 (hH3R) and H4 receptor (hH4R) ligands among a series of NG-acylated imidazolylpropylguanidines, which were originally designed as histamine H2 receptor (H2R) agonists. Aiming at selectivity for hH4R, the acylguanidine group was replaced with related moieties. Within a series of cyanoguanidines, ...

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Item Type:Article
Date:30 September 2009
Additional information (public):Supporting Information available online
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1021/jm900526hDOI
19791743PubMed ID
Related URLs:
URLURL Type
http://pubs.acs.org/doi/suppl/10.1021/jm900526h/suppl_file/jm900526h_si_001.pdfSupplementary Material
Keywords:acylguanidine; cyanoguanidine; histamine H3 receptor; histamine H4 receptor; UR-PI376; UR-PI97
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:15 Sep 2009 11:32
Last Modified:15 Oct 2009 06:31
Item ID:6012
Owner Only: item control page
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