Walenzyk, T. and Koenig, B. (2005) Immobilised Zinc (II) Cyclen complexes as catalytic reagents for phosphodiester hydrolysis. Inorg. Chim. Acta 358, 2269 - 2274.
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Many hydrolases found in nature have Zn(II) ions at their active site. Artificial hydrolases as alternatives for non-enzymatic hydrolysis were prepared by attaching Zn(II) cyclen complexes with an alcohol pendant to a polymeric support. These modified polymers showed a 104-fold enhanced intrinsic reactivity for the hydrolysis of activated phosphodiesters over the non-catalysed reaction
|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König|
|Keywords:||Phosphoester hydrolysis; Immobilised metal complexes; Zinc (II) cyclen|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||05 Mar 2009 10:54|
|Last Modified:||10 Mar 2011 11:31|