Deutsch
Kruppa, M. and Bonauer, C. and Michlová, V. and König, B. (2005) Enhanced Peptide β-Sheet Affinity by Metal to Ligand Coordination. J. Org. Chem. 70, 5305 - 5308.
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Abstract
A histidine-coordinating metal complex substituted with methoxypyrrole amino acids (MOPAS) as a peptide β-sheet binder shows high affinity for a H2N−His-Leu-Leu-Val-Phe-OMe pentapeptide in DMSO solution. Within the complex, a β-sheet conformation is induced into the pentapeptide by weak intra-assembly interactions with the MOPAS units.
| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Institutions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König | ||||
| Projects: | GRK 760, Graduiertenkolleg Medizinische Chemie | ||||
| Identification Number: |
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| Subjects: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Owner: | Regina Hoheisel | ||||
| Deposited On: | 05 Mar 2009 11:54 | ||||
| Last Modified: | 09 Nov 2010 11:26 | ||||
| Item ID: | 6259 |
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