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Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor

Vomasta, D. and Högner, C. and Branda, N. R. and König, B. (2008) Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor. Angew. Chem. 120, pp. 7756-7759.

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Abstract

Photoswitchable: The activity of a dithienylethene-based human carbonic anhydrase inhibitor (hCAI) can be regulated using light. Converting the flexible, ring-open isomer of the photoswitch into the rigid, ring-closed isomer using UV light reduces the inhibition and increases the activity of hCAI by 50-fold. The inhibitor can be turned back on by using visible light, which has many advantages in ...

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Item Type:Article
Date:2008
Additional information (public):auch erschienen in: Angew. Chem. Int. Ed 47, 7644 - 7647 (2008)
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1002/anie.200802242DOI
18767093 PubMed ID
Keywords:carbonic anhydrase · enzyme catalysis · inhibitors · molecular switches · photochromism
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:05 Mar 2009 10:55
Last Modified:08 Nov 2010 12:46
Item ID:6298
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