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Carbonic anhydrase inhibitors: Two-prong versus mono-prong inhibitors of isoformsI, II, IX and XII exemplified by photochromics cis-1,2-a-dithienylethene derivates

Vomasta, Daniel and Innocenti, A. and König, Burkhard and Supuran, T. (2009) Carbonic anhydrase inhibitors: Two-prong versus mono-prong inhibitors of isoformsI, II, IX and XII exemplified by photochromics cis-1,2-a-dithienylethene derivates. Bioorganic & Medicinal Chemistry Letters 19, pp. 1283-1286.

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Abstract

We investigated the inhibition of five physiologically relevant CA isoforms with photochromic cis-1,2-adithienylethene- based compounds incorporating either a benzenesulfonamide and Cu(II)-iminodiacetic acid (IDA)-, bis-benzenesulfonamide-, bis-Cu(II)-IDA-, and bis-ethyleneglycol-methyl ether moieties, in both their open- and closed-ring forms. For hCA I the best inhibitors were the mono-prong ...

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Item Type:Article
Date:2009
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1016/j.bmcl.2009.01.079DOI
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Regina Hoheisel
Deposited On:05 Jun 2009 14:11
Last Modified:08 Nov 2010 10:18
Item ID:7286
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