Gleich, Otto and Weiss, Marianne and Strutz, Jürgen (2004) Age-dependent changes in the lateral superior olive of the gerbil (Meriones unguiculatus). Hearing research 194 (1-2), pp. 47-59.
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Data from humans and animal models provide evidence for an age-dependent impairment in the ability to localize sound. The lateral superior olive (LSO) in the ascending auditory pathway is one important center involved in processing of binaural auditory stimuli. To identify potential age-dependent changes we characterized the LSO in young (< 15 months) and old (> or =3 years) gerbils with a special emphasis on the expression of GABA- and glycine-like immuno-reactivity. The dimensions of the LSO, as well as the number and density of glycine- and GABA-immuno-reactive neurons, were not significantly different between young and old gerbils. The size of glycine- and GABA-immuno-reactive neurons was significantly reduced in the high-frequency (medial) limb of the LSO. Over all, age-dependent changes in the LSO of the gerbil were small.
|Institutions:||Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 590 Zoological sciences
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||18 Jun 2009 14:26|
|Last Modified:||05 Aug 2009 13:57|