Gleich, Otto and Hamann, Ingo and Klump, Georg M. and Kittel, Malte and Strutz, Jürgen (2003) Boosting GABA improves impaired auditory temporal resolution in the gerbil. Neuroreport 14 (14), pp. 1877-1880.
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Elderly humans often not only experience peripheral hearing loss but also suffer from more central deficits in temporal auditory processing affecting speech perception. Impaired auditory temporal resolution has also been observed in old rodents. Other studies have demonstrated a reduction of GABAergic function in the auditory pathway of old animals. Here we test the hypothesis that deficits in the GABAergic system affect central auditory processing. Our data suggests that pharmacological augmentation of the GABAergic system ameliorates impaired temporal auditory processing in the gerbil and might be a strategy for the treatment of at least some forms of central hearing loss in humans.
|Institutions:||Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 590 Zoological sciences
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||18 Jun 2009 14:30|
|Last Modified:||05 Aug 2009 13:57|