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Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis

Farkas, Stefan and Hornung, Matthias and Sattler, Christine and Edtinger, Karoline and Steinbauer, Markus and Anthuber, Matthias and Schlitt, Hans J. and Herfarth, Hans and Geissler, Edward K. (2006) Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis. International journal of colorectal disease 21 (1), pp. 71-78.

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Other URL: http://dx.doi.org/10.1007/s00384-004-0709-y


Abstract

BACKGROUND: Leukocyte recruitment to sites of intestinal inflammation is a crucial multi-step process, leading ultimately to the accumulation of cells in the inflamed tissue. These interactions in the gut are critically dependent on the mucosal addressin cell adhesion molecule-1 (MAdCAM-1), which is expressed on endothelial cells within the mesenteric lymph nodes and the lamina propria of the ...

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Item Type:Article
Date:January 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
15856265PubMed ID
10.1007/s00384-004-0709-yDOI
Keywords:MAdCAM-1; Experimental chronic colitis; In vivo microscopy
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Ute Lange
Deposited On:06 Dec 2006
Last Modified:13 Mar 2014 09:42
Item ID:770
Owner Only: item control page

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