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Anti-TNF antibody treatment improves glucocorticoid induced insulin-like growth factor 1 (IGF1) resistance without influencing myoglobin and IGF1 binding proteins 1 and 3

Sarzi-Puttini, P. and Atzeni, F. and Schölmerich, J. and Cutolo, M. and Straub, R. H. (2006) Anti-TNF antibody treatment improves glucocorticoid induced insulin-like growth factor 1 (IGF1) resistance without influencing myoglobin and IGF1 binding proteins 1 and 3. Annals of the rheumatic diseases 65 (3), pp. 301-5.

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Other URL: http://dx.doi.org/10.1136/ard.2005.040816


Abstract

BACKGROUND: Insulin-like growth factor 1 (IGF1) is an important determinant of muscle mass because it promotes growth and suppresses protein degradation. IGF1 is decreased in rheumatoid arthritis and juvenile idiopathic arthritis because its synthesis is inhibited by inflammation. In parallel, glucocorticoids induce IGF1 resistance and add to muscle degradation. OBJECTIVE: To investigate the ...

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Item Type:Article
Date:March 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
16079165PubMed ID
10.1136/ard.2005.040816DOI
Keywords:rheumatoid arthritis; adalimumab; insulin-like growth factor 1; IGF1 binding protein-1; IGF1 binding protein-3
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:06 Dec 2006
Last Modified:13 Mar 2014 09:42
Item ID:773
Owner Only: item control page

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