Anti-TNF antibody treatment improves glucocorticoid induced insulin-like growth factor 1 (IGF1) resistance without influencing myoglobin and IGF1 binding proteins 1 and 3

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.773

Sarzi-Puttini, P. ; Atzeni, F. ; Schölmerich, J. ; Cutolo, M. ; Straub, R. H.

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:24

Alternative Links zum Volltext:Pubmed DOI Verlag

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BACKGROUND: Insulin-like growth factor 1 (IGF1) is an important determinant of muscle mass because it promotes growth and suppresses protein degradation. IGF1 is decreased in rheumatoid arthritis and juvenile idiopathic arthritis because its synthesis is inhibited by inflammation. In parallel, glucocorticoids induce IGF1 resistance and add to muscle degradation. OBJECTIVE: To investigate the ...