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Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma

Hellerbrand, Claus and Mühlbauer, Marcus and Wallner, Susanne and Schuierer, Marion and Behrmann, Iris and Bataille, Frauke and Weiss, Thomas and Schölmerich, Jürgen and Bosserhoff, Anja-Katrin (2006) Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. Carcinogenesis 27 (1), pp. 64-72.

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Other URL: http://dx.doi.org/10.1093/carcin/bgi201


Abstract

The methylthioadenosine phosphorylase (MTAP) gene is localized in the chromosomal region 9p21. Here, frequently homozygous deletions occur in several kinds of cancer associated with the loss of tumour suppressor genes as p16 and p15. The aim of this study was to analyse MTAP expression in hepatocellular carcinoma (HCC) and to get an insight into the regulation and functional role of MTAP in ...

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Item Type:Article
Date:January 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
10.1093/carcin/bgi201DOI
16081515PubMed ID
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:07 Dec 2006
Last Modified:13 Mar 2014 09:42
Item ID:775
Owner Only: item control page
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