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Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb

Winner, Beate and Geyer, Martin and Couillard-Despres, Sebastien and Aigner, Robert and Bogdahn, Ulrich and Aigner, Ludwig and Kuhn, Georg and Winkler, Jürgen (2006) Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb. Experimental neurology 197 (1), pp. 113-121.

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Other URL: http://dx.doi.org/10.1016/j.expneurol.2005.08.028


Dopaminergic loss is known to be one of the major hallmarks of Parkinson disease (PD). In addition to its function as a neurotransmitter, dopamine plays significant roles in developmental and adult neurogenesis. Both dopaminergic deafferentation and stimulation modulate proliferation in the subventricular zone (SVZ)/olfactory bulb system as well as in the hippocampus. Here, we study the impact of ...


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Item Type:Article
Date:January 2006
Institutions:Medicine > Lehrstuhl für Neurologie
Identification Number:
16246330PubMed ID
Keywords:Parkinson disease; Lesion; Adult neurogenesis; Neural progenitor/stem cell; BrdU; TH; Pax-6; Cell fate; 6-OHDA
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:07 Dec 2006
Last Modified:13 Mar 2014 09:42
Item ID:789
Owner Only: item control page


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