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Targeted tumor therapy with the TGF-beta2 antisense compound AP 12009

Schlingensiepen, Karl-Hermann and Schlingensiepen, Reimar and Steinbrecher, Andreas and Hau, Peter and Bogdahn, Ulrich and Fischer-Blass, Birgit and Jachimczak, Piotr Targeted tumor therapy with the TGF-beta2 antisense compound AP 12009. Cytokine & growth factor reviews 17 (1-2), pp. 129-139.

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Other URL: http://dx.doi.org/10.1016/j.cytogfr.2005.09.002


Abstract

TGF-beta overexpression is a hallmark of various malignant tumors. This is due to the pivotal role of TGF-beta as it regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. We have developed a new immunotherapeutic approach for the treatment of malignant tumors based on the specific inhibition of TGF-beta2 by the antisense ...

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Item Type:Article
Institutions:Medicine > Lehrstuhl für Neurologie
Identification Number:
ValueType
10.1016/j.cytogfr.2005.09.002DOI
16377233PubMed ID
Keywords:TGF-β; High-grade gliomas; Pancreatic carcinoma; Malignant melanoma; Antisense oligodeoxynucleotides
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:08 Dec 2006
Last Modified:13 Mar 2014 09:43
Item ID:805
Owner Only: item control page
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