Schlingensiepen, Karl-Hermann and Schlingensiepen, Reimar and Steinbrecher, Andreas and Hau, Peter and Bogdahn, Ulrich and Fischer-Blass, Birgit and Jachimczak, Piotr (2006) Targeted tumor therapy with the TGF-beta2 antisense compound AP 12009. Cytokine & growth factor reviews 17 (1-2), pp. 129-139.
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TGF-beta overexpression is a hallmark of various malignant tumors. This is due to the pivotal role of TGF-beta as it regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. We have developed a new immunotherapeutic approach for the treatment of malignant tumors based on the specific inhibition of TGF-beta2 by the antisense ...
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|Institutions:||Medicine > Lehrstuhl für Neurologie|
|Keywords:||TGF-β; High-grade gliomas; Pancreatic carcinoma; Malignant melanoma; Antisense oligodeoxynucleotides|
|Dewey Decimal Classification:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited on:||08 Dec 2006|
|Last modified:||28 Jul 2015 12:54|