Defects in N-glycosylation induce apoptosis in yeast

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.85

Hauptmann, Peter ; Riel, Constanze ; Kunz-Schughart, Leoni A. ; Fröhlich, Kai-Uwe ; Madeo, Frank ; Lehle, Ludwig

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:21

Alternative Links zum Volltext:DOI Verlag

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Zusammenfassung

N-glycosylation in the endoplasmic reticulum is an essential protein modification and highly conserved in evolution from yeast to man. Defects of N-glycosylation in humans lead to congenital disorders. The pivotal step of this pathway is the transfer of the evolutionarily conserved lipid-linked core-oligosaccharide to the nascent polypeptide chain, catalysed by the oligosaccharyltransferase. One ...