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Defects in N-glycosylation induce apoptosis in yeast

Hauptmann, Peter and Riel, Constanze and Kunz-Schughart, Leoni A. and Fröhlich, Kai-Uwe and Madeo, Frank and Lehle, Ludwig (2006) Defects in N-glycosylation induce apoptosis in yeast. Molecular Microbiology 59 (3), pp. 765-778.

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Other URL: http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2958.2005.04981.x


Abstract

N-glycosylation in the endoplasmic reticulum is an essential protein modification and highly conserved in evolution from yeast to man. Defects of N-glycosylation in humans lead to congenital disorders. The pivotal step of this pathway is the transfer of the evolutionarily conserved lipid-linked core-oligosaccharide to the nascent polypeptide chain, catalysed by the oligosaccharyltransferase. One ...

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Item Type:Article
Date:February 2006
Institutions:Biology, Preclinical Medicine > Institut für Botanik / Zellbiologie
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.1111/j.1365-2958.2005.04981.xDOI
Subjects:500 Science > 580 Botanical sciences
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:19 Jul 2006
Last Modified:13 Mar 2014 09:38
Item ID:85
Owner Only: item control page
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