Drug delivery from bioerodible polymers: systemic and intravenous administration

Abstract

The recent progress in understanding the erosion of
biodegradable polymers and the manufacturing of controlled
release devices for proteins and peptides is reported. The
erosion mechanism of poly(anhydrides) was investigated as
an example of biodegradable polymers and the erosion behavior
is modeled mathematically. The results provide useful
information on the microstructure and chemical environment
inside these polymers during erosion. It is shown how they
might affect the stability and the release of proteins.
Concomitantly proteins were processed in controlled release
devices. Special attention was paid to the stability of the
biomolecules during the manufacturing of dosage forms.
Furthermore, the development of a new type of biodegradable
nanosphere as a future dosage form is shown.