Göpferich, Achim and Gref, Ruxandra and Minamitake, Yoshiharu and Shieh, Lisa and Alonso, Maria Jose and Tabata, Yashuhiko and Langer, Robert S. (1994) Drug delivery from bioerodible polymers: systemic and intravenous administration. In: Cleland, Jeffrey L., (ed.) Formulation and delivery of proteins and peptides. ACS symposium series, 567. American Chemical Soc., Washington, DC, pp. 242-277. ISBN 0-8412-2959-7.
The recent progress in understanding the erosion of
biodegradable polymers and the manufacturing of controlled
release devices for proteins and peptides is reported. The
erosion mechanism of poly(anhydrides) was investigated as
an example of biodegradable polymers and the erosion behavior
is modeled mathematically. The results provide useful
information on the microstructure and chemical environment
inside these polymers during erosion. It is shown how they
might affect the stability and the release of proteins.
Concomitantly proteins were processed in controlled release
devices. Special attention was paid to the stability of the
biomolecules during the manufacturing of dosage forms.
Furthermore, the development of a new type of biodegradable
nanosphere as a future dosage form is shown.
|Item Type:||Book Section|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)|
|Subjects:||500 Science > 570 Life sciences|
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Deposited On:||14 Aug 2009 10:32|
|Last Modified:||20 Jul 2011 21:36|