Dummer, Reinhard and Nestle, Frank and Wiede, Johannes and Schäfer, Erwin and Röger, Jürgen and Becker, Jürgen C. and Vogt, Thomas and Burg, Günter (1991) Coincidence of increased soluble interleukin-2 receptors, diminished natural killer cell activity and progressive disease in cutaneous T-cell lymphomas. European Journal of Dermatology 1, pp. 135-138.
In 24 patients with cutaneous T-cell lymphomas (CTCL) the clinical course was documented by determination of a tumour burden index (TBI) on entering the study and six months later. In addition to the first TBI, soluble interleukin-2 receptor levels (slL-2R) in the serum were determined using an ELISA technique in 23 patients. In 18 patients natural killer cell (NK) activity was assessed by a 4 h chromium-51 release assay. Statistical analysis revealed a negative correlation between NK activity and an increase of TBI as well as NK activity and slL-2R. Furthermore, there was a strong positive correlation between the increase of TBI and slL-2R. slL-2R and NK activity might be prognostic factors in CTCL patients.
|Institutions:||Medicine > Lehrstuhl für Dermatologie und Venerologie|
|Keywords:||cutaneous T-cell lymphomas; soluble interleukin-2 receptor; natural killer cell activity; prognostic factors|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||24 Aug 2009 14:31|
|Last Modified:||20 Jul 2011 21:39|