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Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex.

Knechtle, Stuart J. and Wang, Jue and Jiao, Shoushu and Geissler, Edward K. and Sumimoto, Ryo and Wolff, Jon (1994) Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. Transplantation® 57 (7), pp. 990-996.

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Abstract

Induction of tolerance to allogeneic MHC antigens has been a goal in the field of transplantation because it would reduce or eliminate the need for generalized immunosuppression. Although encouraging results have been obtained in experimental models by exposing recipient thymus to donor cells before transplantation, donor cells are not typically available at that time, and the donor antigens ...

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Item Type:Article
Date:1994
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
7839422PubMed ID
Classification:
NotationType
AnimalsMESH
Cells, CulturedMESH
Graft SurvivalMESH
Histocompatibility Antigens Class I/geneticsMESH
Immune ToleranceMESH
Immunotherapy, AdoptiveMESH
Liver Transplantation/immunologyMESH
MaleMESH
Muscles/immunologyMESH
RatsMESH
Rats, Inbred ACIMESH
Rats, Inbred LewMESH
T-Lymphocytes, Cytotoxic/cytologyMESH
Thymus GlandMESH
TransfectionMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Universitätsbibliothek Regensburg
Deposited On:22 Sep 2009 12:13
Last Modified:13 Mar 2014 11:02
Item ID:9553
Owner Only: item control page

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