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Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle.

Geissler, Edward K. and Wang, Jue and Fechner, John H. and Burlingham, William J. and Knechtle, Stuart J. (1994) Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle. The Journal of Immunology 152 (2), pp. 413-421.

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Abstract

Plasmid cDNA encoding the alpha-chain of either membrane-bound (pcRT.45) or secreted (pcRQ.B3) RT1Aa MHC class I Ag were transferred to Lewis (RT1(1)) rat skeletal muscle by direct injection. Rats were challenged 7 days later with an ACI (RT1a) heterotropic heart transplant, and cardiac allograft survival, RT1Aa-specific antibody levels, and frequency of ACI-specific CTL were monitored. Graft ...

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Item Type:Article
Date:1994
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
8283029PubMed ID
Classification:
NotationType
AnimalsMESH
Base SequenceMESH
DNA Primers/chemistryMESH
Gene Transfer TechniquesMESH
Genes, MHC Class IMESH
Graft SurvivalMESH
Heart Transplantation/immunologyMESH
Histocompatibility Antigens Class I/immunologyMESH
Molecular Sequence DataMESH
MusclesMESH
RatsMESH
Rats, Inbred LewMESH
T-Lymphocytes, Cytotoxic/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Universitätsbibliothek Regensburg
Deposited On:22 Sep 2009 12:10
Last Modified:13 Mar 2014 11:02
Item ID:9554
Owner Only: item control page
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