Deutsch
URN to cite this document: urn:nbn:de:bvb:355-opus-671
Köhler, Jens (2002) Untersuchungen zur Pharmakokinetik und Pharmakodynamik verschiedener galenischer Formulierungen des Immunsuppressivums Cyclosporin A vor und nach Nierentranplantation an Ratten. PhD, Universität Regensburg
![[img]](http://epub.uni-regensburg.de/style/images/fileicons/application_pdf.png)
| Publishing license for publications excluding print on demand PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 5Mb |
Abstract (German)
Ziel der Arbeit war der Vergleich der therapeutischen Äquivalenz des Immunsuppressivums Sandimmun Neoral mit zwei Generika, Gengraf und CsA Eonlabs.
Es konnten siqnifikante Unterschiede im first-pass Metabolismus zwischen den drei Pharmaka festgestellt werden. Des Weiteren wurden Untersuchungen zum Metabolismus des Cyclosporin A und verschiedenen mRNA Abundanzen in den Nieren nach Nierentransplantation in Ratten durchgeführt.
Translation of the abstract (English)
In this work, the therapeutic equivalence of sandimmun neoral and two generic preparations, gengraf and CsA eonlabs was investigated. It became evident, that there exist significant differences in the first pass metabolism between these three medicinal products. Further, dose dependent effects on the metabolism of cyclosporine A and on differnt mRNA expressions in the kidneys after orthotopic kidney transplantations were performed, too.
| Item Type: | Thesis of the University of Regensburg (PhD) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Referee: | Horst F.; Prof.Dr.med. Grobecker | ||||||||
| Date of exam: | 12 April 2002 | ||||||||
| Additional information (public): | Drug Metabolism and Disposition (ASPET) | ||||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy | ||||||||
| Classification: |
| ||||||||
| Keywords: | Cyclosporine , Nierentransplantation , Ratten , Pharmakokinetik , Pharmakodynamik , Generika , Immunsuppressiva , Generics , immunosuppressive drugs | ||||||||
| Subjects: | 500 Science > 540 Chemistry & allied sciences | ||||||||
| Status: | Published | ||||||||
| Refereed: | Yes, this version has been refereed | ||||||||
| Created at the University of Regensburg: | Yes | ||||||||
| Owner: | Universitätsbibliothek Regensburg | ||||||||
| Deposited On: | 21 Oct 2009 15:40 | ||||||||
| Last Modified: | 12 Nov 2012 14:49 | ||||||||
| Item ID: | 9912 |
- ASCII Citation
- BibTeX
- Dublin Core
- EndNote
- HTML Citation
- METS
- OAI-ORE Resource Map (Atom Format)
- OAI-ORE Resource Map (RDF Format)
- RDF+N-Triples
- RDF+N3
- RDF+XML
- Refer
- Reference Manager
- Simple Metadata
- XML
- xMetaDissPlus
Literature of the same author
in this repositoryat BASEat Google Scholarat ScirusBookmark
Citeulike
Connotea
Del.icio.us
Digg
Facebook