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(+)-(s)-acetylmandelic acid (acetoxyphenyl)indene deriv. binding by *Brain Ischemia: DT *Brain Ischemia: EN *Chemistry *Enzyme Inhibitors: PD *Matrix Metalloproteinases: AI 0 (Enzyme Inhibitors) 0 (Tumor Necrosis Factor-alpha) 1-(2 1-dicarboxylato]platinum(II) 15-Lipoxygenase 2 2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1 2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) Amines Role: BAC (Biological activity or effector 2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) Antitumor agents (prepn. and stereoselectivity in antitumor activity of [1 2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) platinum diaminophenylpropane chloro prepn antitumor activity stereoselectivity antitumor activity platinum diaminophenylpropane chloro phenylpropanediamine platinum chloro prepn antitumor activity diamine platinum chloro prepn antitumor activity conformation platinum diaminophenylpropane chloro isomer 2-Guanidinothiazole 3 3-lactone 3D-QSAR 4 6-dic Structure-activity relationship (antitumor [Aqua-1-(2 6-Dichloro-4-hydroxyphenyl)-2-phenylethanes 6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Antitumor agents (mammary gland [Aqua-1-(2 6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) antitumor breast phenylethylenediamine platinum complex 6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Estrogens Role: BAC (Biological activity or effector 6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Mammary gland (neoplasm 6-tetra-O-acetyl--D-glucopyranosyl isothiocyanate 6-tetra-O-acetyl-1-thio--D-glucopyranoside a novel a(2a) adenosine receptor crystal-structure amino-acid beta(2)-adrenergic receptor structural instability adrenergic-receptor guinea-pig activation rhodopsin state ABC transporter ABC-Transporter ABCA1 ABCB1 ABCG2 Acyl guanidines Acylation Acylgruppe Acylguanidin Acylguanidine acylguanidines ADAM Proteins Adenylyl cyclase Adenylyl cyclase . Bacillus anthracis . Edema factor .MANT nucleotide . Molecular modelling . Fluorescence spectroscopy Aequorin Affymetrix gene chips Agonist Akute myeloische Leukämie alignment rules ALR Amide Amino acids Role: RCT (Reactant) Aminothiazol aminothiazole and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Antitumor agents (mammary gland prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Mammary gland (neoplasm and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Solubility (water soly. of platinum fluorophenylethylenediamine dicarboxylato complexes) fluorophenylethylenediamine dicarboxylato platinum complex prepn antitumor activity platinum fluorophenylethylenediamine dicarboxylato complex soly fluorophenylethylenediamine dicarboxylato platinum complex nucleophilic substitution kinetics fluorophenylethylenediamine dicarboxylatoplatinum complex and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II) Animal Animals Antagonist antagonists & inhibitors Antiestrogen Antiestrogene Antiestrogens antigen antimicrobials / hyaluronidase / molecular mechanism / pneumococci / spreading factor antitumor activity platinum chloro aminoethoxyestrone aminoethoxyestradiol antitumor activity platinum fluorophenylethylenediamine complex platinum fluorophenylethylenediamine diastereoisomer complex ethylenediamine fluorophenyl platinum diastereoisomer complex Antitumor agents Antitumor agents ([rac-1 Antitumor agents (brain hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors) Antitumor agents (mammary gland platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) Mammary gland (neoplasm antitumor effect) antitumor vinblastine hyaluronidase interaction Antiöstrogene Apo-E Apoenzym Apolipoprotein A Apoptosis Aralkylgruppe Argininamid Argininamid BIBP 3226 argininamide argininamide BIBP 3226 argininamide derivatives argininamides Argininderivate arpromidine Arteriosklerose arylbenzimidazoles ascorbic acid derivatives Assay assays at high temp. and pressure atherosclerosis Atherosklerose autoradiography Bacteria (thermophilic BCNU BCRP bee venom hyaluronidase Benzimidazole-2-thiones Benzoxazol-2-thion benzoxazole-2-thione Benzoxazole-2-thiones beta-arrestins beta2-syntrophin BIBP 3226 BIIE 0246 BIIE0246 binding affinity Biodegradable polymer Bioisostere bioisosteric replacement Bioisosterie bioisosterism bioisoterism BIOL (Biological study) BIOL (Biological study) (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) platinum chloro fluorohydroxyphenylethylenediamine prepn antitumor breast cancer biological response modifiers Biologische Aktivität biscycloalkylamineplatinum dichloro antitumor prepn structure bivalent ligand bivalent ligands Bivalente Liganden bivalenter Ligand Bladder blood-brain barrier Blut Blut-Hirn-Schranke BODIPY Bovine testicular hyaluronidase bovine testikuläre Hyaluronidase BPR (Biological process) Brain Brain cancer brain tumors breast cancer cells bridging ligands Brustkrebs Brustkrebszellen BSU (Biological study Buoyant density separation Calcein-AM Calcium Calcium Assay calcium mobilization cancer carboplatin deriv anticancer carboplatin deriv prepn carboplatin derivs. with superior antitumor activity compared to the parent compd.) carcinoma Cardiotonics CD-Spektroskopie cell surface Chaotropic agent Chemie Chemische Synthese chemosensitivity human melanoma cell cytostatic chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion) chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy) Chemotaxis Chemotherapie child brain tumor chemotherapy hyaluronidase combination Chimeric G protein chimeric G-protein chimeric receptors chimäres G-Protein chiral chiral HPLC Cholesterinstoffwechsel circular dichroism clozapine analogues Colitis ulcerosa colon Colorectal carcinoma CoMFA complement C1q C-chain composition (lactate dehydrogenase of confocal microscopy confocal miroscopy Conformation Stereochemistry (antitumor potency of diastereomeric and enantiomeric platinum diaminophenylpropane dichloro complexes in relation to) Structure-activity relationship (antitumor stereoselectivity of antitumor active [1 conformational restriction constitutive activity Cope rearrangement (of bis(hydroxyphenyl)ethylenediamine reaction products with fluorobenzaldehyde) Coumarin CpG-Methylierung CRE Cross-coupling Cyanine Cyanoguanidin cyanoguanidine cyanoguanidines cycloaddition cyclobond cyclodextrins Cytokin cytotoxicity Darmkrebs decay kinetics adjustment Degradation rate Dendritische Zelle Deoxyribonucleic acids Role: BPR (Biological process) Dephosphorylatin Development (child diastereomeric derivatives dichlorobis(cycloalkylamine)platinum(II) complexes as dichlorobiscycloalkylamineplatinum antitumor prepn structure Differentielle Genexpression dimerisation Diphenylfuran DNA formation ([Aqua-1-(2 DNS-Bindung Doxorubicin Doxorubicin-Nanopartikel Drosophila Schneider-2 Zellen Drug distribution Drug interactions (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy) drug therapy Dunning R3327-G tumour Dunning R3327-MatLu tumour Durchflusscytometrie Durchflusszytometrie E-LDL EC 3.4.24.- (ADAM Proteins) EC 3.4.24.- (Matrix Metalloproteinases) EC 3.4.24.- (Metalloendopeptidases) EC 3.4.24.- (tumor necrosis factor-alpha convertase) EC 3.4.24.24 (Matrix Metalloproteinase 2) EC 3.4.24.35 (Matrix Metalloproteinase 9) Einschlusskörper Elacridar Elektronensprayionisations-Massenspektrometrie enantiomers Endocrine therapy Endocytosis rate Endokrine Therapie endoperoxides Endosomal sorting Endosome Entzündung enzyme inhibitor Enzyminhibitor Enzymologie enzymology Eosinophils Epac Epithelzelle equilibrium estradiol aminoethoxy platinum chloro estrogen receptor estrogen receptor affinity estrogen receptor subtype Estrogen receptor β Estrogen Rezeptor Estrogen Rezeptor Subtyp estrogenic/antiestrogenic activity estrone aminoethoxy platinum chloro except adverse) extracellular domains extracellular loops Festphasenpeptidsynthese Festphasensynthese Festphasentechnik Fever and Hyperthermia (chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion) Fibroblast flow cytometry fluorescence fluorescence ligand fluorescence spectroscopy fluorescent ligand fluorescent ligands Fluorescent probe fluorescent probes fluorescent proteins Fluoreszenz Fluoreszenz Mikroskopie Fluoreszenz-Resonanz-Energie-Transfer Fluoreszenzligand Fluoreszenzspektroskopie fluorimetric Fluorimetrie fluorimetrisch fluorophenyl ethylendiamine cyclobutane carboxylatoplatinum synthesis anticancer fluorophenylethylenediaminedichloroplatinum complex prepn stability neoplasm inhibition foam cells folate receptor beta FORM (Formation FRET Functional selectivity Fura-2 Furanderivate Fusionsprotein G protein coupled receptor G protein regulation G protein-coupled receptor G-protein G-protein coupled receptor G-Protein gekoppelter Rezeptor G-Protein-gekoppelter Rezeptor Gastrointestinaler Tumor gene therapy Genexpression Genregulation Gentherapie Gi protein family Gi/Go-proteins Glioblastom glioblastoma glucurono-6 Glykosphingolipide Glykosylierung GPCR GRKs GTPase GTPase assay GTPase-Assay GTPyS Guanidin Guanidinderivate Guanidines guanidinium compounds guanidinylation Guanidinylierung H2 receptor agonist h2 receptor agonists h2 receptor antagonists H2 receptor model H2-receptor H2-Rezeptor H3-receptor H3-Rezeptor H4 receptor H4 receptor agonist H4 receptor selectivity H4-receptor H4-Rezeptor Hals-Nasen-Ohren-Tumor Heart Heat (on biol. mols. and microorganisms) heat thermophilic bacteria degrdn amino acid degrdn heat pressure peptide degrdn heat pressure HEK293 cells HEK293 Zellen Helix-loop-Helix hematoporphyrin platinum amine prepn antitumor photodynamic therapy Hep27 (DHRS2) heparin hepatocellular carcinoma Hepatozellular Karzinoma Herpesvirus saimiri Heterocyclische Verbindungen high temp. and pressure effect on amino acids of High-density-Lipoproteine highly active carboplatin deriv. Hill slope Hirnmetastase Hirntumor Histamin Histamin H2 Rezeptor Agonist Histamin-H2-Rezeptor histamine Histamine agonists Histamine H1 receptor antagonists histamine H2 receptor histamine H2 receptor agonist histamine H2 receptor agonists Histamine H2 receptor antagonists Histamine H2-receptor agonist histamine H3 receptor histamine H4 receptor Histamine H4-receptor Histamine H₁ receptor Histamine H₂ receptor histamine receptors Histaminrezeptor Histaminrezeptorsynergist HLH motif Hoechst 33342 Hormon-abhängiger Brustkrebs Hormone-dependent breast cancer Hormone-dependent brest cancer Hospitalismus <Hygiene> Huisgen reaction Human Hyal-1 Hyaluronan hyaluronan analytics Hyaluronan lyase inhibitors Hyaluronan lyases hyaluronate lyase hyaluronic acid hyaluronidase hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors) Hyaluronidase inhibitors Hyaluronidase inhibitors • LUDI • Property distribution • Structure-based design Hyaluronidasen hyaluronidases Hyaluronsäure Hyaluronsäure-Analytik Hydrolysis kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes) Substituent effects (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes vs. breast cancer cytotoxicity) Substitution reaction kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes with iodide) Antitumor agents (platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes as) platinum bisfluorophenylethylenediamine acetate deriv prepn cytotoxicity fluorophenylethylenediamine platinum acetate deriv prepn cytotoxicity cytotoxicity platinum bisfluorophenylethylenediamine acetate deriv substituent kinetics substitution platinum bisfluorophenylethylenediamine acetate deriv breast cancer cytotoxicity platinum bisfluorophenylethylenediamine acetate diastereoisomer platinum bisfluorophenylethylenediamine acetate prepn cytotoxicity hyperthermic limb perfusion cytostatic chemosensitivity Id Proteine Id proteins Id3 Protein Imidazol imidazole imidazolylpropylguanidine immunosuppression Immunsuppression Impromidine impromidine analogues indole-3-butyric acid indoles inflammation Inhibitor Inhibitorproteine inhibitors inhibitors [Aqua-1-(2 inhibitors platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) platinum fluorophenylethylenediamine DMSO prepn breast antitumor agent inhibitors prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Substitution reaction kinetics (nucleophilic of platinum fluorophenylethylenediamine dicarboxylato complexes with iodide) Carboxylic acids Role: BAC (Biological activity or effector innate immunsystem Interleukin-11 Intracellular calcium concentration Ischemia Isolierung <Chemie> Isotopenmarkierung JNJ7777120 K+-channel-inhibitors Kalium-Kanal-Inhibitoren Kaliumkanal Kapillarelektrophorese Kinesin Kinesin Eg5 Kinesin inhibitors - Monastrol analogues - Human glioblastoma cells - Chemosensitivity - Confocal microscopy Kinetics kinetics of) Konformation Konformationsanalyse Konstitutive Aktivität Krebs <Medizin> Krebszelle labeled ligand Lactam formation lactate dehydrogenase subunit assembly Leber Leberregeneration Leberzellkrebs Ligand <Biochemie> Limb perfusion • Rat • Online monitoring • Oxygen-microoptodes • Perfusion pressure Limited proteolysis Lipid efflux Lipidefflux Lipophilicity liposomes liver liver regeneration LNCaP prostate carcinoma cells Local therapy Low-density-Lipoproteine lung cancer Lungentumore Lymphotoxin lymphotoxin-beta-receptor Lymphotoxin-beta-Rezeptor Lysosomal sorting Lysosome macrophage migration inhibitory factor Magentumor Magnetische Kernresonanz Malignant brain tumor Malignant melanoma Mammary gland (neoplasm mast cell Mastzelle Matrix Metalloproteinase 2: AI Matrix Metalloproteinase 9: AI MCF-7 breast cancer cells MCP-4 MDR medical applications medicinal chemistry metabolism Metalloendopeptidases: ME Metastases MFM (Metabolic formation) Mitogen-activated protein kinase Models mol. structure) Molecular association (of lactate dehydrogenase subunits molecular design molecular dynamics Molecular modeling * Receptor binding studies molecular modelling Molecular recognition Molecular structure ([rac-1 Molecular structure-biological activity relationship (neoplasm-inhibiting Molekulardesign Molekulardynamik Monozyten-Makrophagen-System multichromophore systems Multidrug-Resistenz Mustererkennung MXT mouse mammary tumour Myelose Nachweis nanoparticles Nanopartikel neoplasm (cisplatin-resistant neoplasm inhibiting activity in relation to) acetoxyphenylindene ethylmethylacetoxy prepn tumor inhibitor indene acetoxyphenyl anticancer Neoplasm inhibitors (acetoxy(acetoxyphenyl)ethylmethylindene) Receptors Role: RCT (Reactant) Neoplasm inhibitors (discrepancy between cytotoxicity and platinum accumulation and DNA platination in MCF-7 breast cancer cells treated with diaqua(diphenylethylenediamine) Neoplasm inhibitors (mammary gland Neoplasm inhibitors (melanoma Neoplasm inhibitors (platinated DNA after treatment of cancer cells with new platinum complexes) Neoplasm inhibitors (platinum ammine chloro complexes with aminoethoxyestrone or -estradiol as) Neoplasm inhibitors (platinum complexes with bis(fluorophenyl)ethylenediamines) Neoplasm inhibitors Role: BAC (Biological activity or effector neoplasms (hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors) neoplasms (inhibitors Neuropeptid Y Neuropeptid Y Y1 Rezeptor Neuropeptid Y Y1-Rezeptorantagonist neuropeptide Y neuropeptide Y Y1 receptor Neuropeptide Y Y1 Receptor Antagonist neuropeptide Y Y2 receptor neuropeptide Y Y4 receptor neutrophil granulocytes NG-Acylguanidine NG-Acylguanidines Nicht-kleinzelliges Bronchialkarzinom NMR-Spektroskopie Noble tumour Non-steroidal estrogen Nonpeptide NPY Y4 receptor antagonist nonpreparative) Nonsteroidal antiandrogen nosocomial infection NPY NPY receptors NPY Rezeptoren NPY Y1 receptor NPY Y4 receptor o-phthaldialdehyde of dichlorobis(cycloalkylamine)platinum(II) complexes) Opsonine opsonins Opsonisierung optical imaging Optisches Imaging Organische Synthese Ornithine decarboxylase OUP-16 Ovary Ox-LDL oximes Oxo-arpromidine P-glycoprotein paclitaxel PDGF receptor PDGF Rezeptor Peptidanaloga Peptide peptide synthesis and characterization Peptidomimetikum Peptidsynthese PGP pH profiles PH-20 pH-Profile Phagozyt Phagozytose Pharmaceutical Germany pharmaceutical carriers Pharmaceutical dosage forms (hydrosols pharmacological in vitro assays pharmacological tools Pharmacologie pharmacology pharmakologische Assays pharmakologische In-vitro-Assays Pharmakologischer Antagonist Pheniramine Phenylpyridylpropylamines Phospholipase C Phosphorylation Photodynamic therapy Photosensitizers Phototoxicity (prepn. of water-sol. platinum porphyrin amine complexes with high tumor selectivity for use in photodynamic therapy) Piperidinomethylalkylamine Platelet-derived Growth Factor Platelet-derived growth factor receptor - Human glioblastoma cells - Imatinib platinum prepn. platinum complex antitumor platinated DNA platinum complex prepn stability neoplasm inhibition platinum complexes prepn. and stereoselectivity in antitumor activity of [1 platinum cycloalkylamine chloro antitumor prepn structure platinum porphyrin amine prepn antitumor photodynamic therapy platinum(II) sulfates and cisplatin in MCF-7 human breast cancer cells) Polyamines Polyanhydride polymer nanoparticles Porphyrins Positronen-Emissions-Tomographie PREP (Preparation) PREP (Preparation) (carboxylic acid PREP (Preparation) (diamines PREP (Preparation) (mammary gland PREP (Preparation) (neoplasm PREP (Preparation) (transition metal complexes prepn. prepn. of prepn. of fluorophenyl- and difluorophenyl(p platinum fluorophenylethylenediamine deriv diastereomer prepn antitumor antitumor breast platinum fluorophenylethylenediamine deriv diastereomer prepn. of fluorophenyl- and difluorophenyl(ph Mammary gland Role: BAC (Biological activity or effector PROC (Process) ([Aqua-1-(2 PROC (Process) (discrepancy between cytotoxicity and platinum accumulation and DNA platination in MCF-7 breast cancer cells treated with diaqua(diphenylethylenediamine) platinum(II) sulfates and cisplatin in MCF-7 human breast cancer cells) platinum compd cytotoxicity DNA platination tumor diaquadiphenylethylenediamine platinum cytotoxicity DNA platination tumor PROC (Process) (platinated DNA after treatment of cancer cells with new platinum complexes) Programmable release Promotor Prostate carcinoma Protein kinase C protein purification Protein-Protein Interaktion Proteine Proteinfaltung Proteinreinigung PRP (Properties) Pulsatile release Punktmutation Pyranderivate Pyrodictium occultum (high temp. and pressure effect on amino acids of qsar Quadratsäureamid RACT (Reactant or reagent) (degrdn. and hydrolysis of RACT (Reactant or reagent) (for estrogens radioactivity Radioaktivität radiochemistry radiolabeled H3 receptor ligand radiolabeled H4 receptor ligand radiolabeled Y1 receptor antagonist radioligand radioligand kinetics Rafts Rats reaction (of lactate dehydrogenase subunit assembly) receptor Receptor affinity Receptor conservation receptor internalization receptor selectivity receptor selectivity GTPase assay aminothiazoles receptor species orthologs receptors recombinant protein Regeneration Rekombinantes Protein Rezeptor RGS protein rheumatoid arthritis rheumatoide Arthritis Rigidisierung RNAi RNS Role: PAC (Pharmacological activity) Route of application SAR Schaumzelle Schaumzellen SDS–PAGE Selective agonist endocytosis Sepsis Sf9 cells Sf9 insect cells Sf9-Insektenzellen singlet oxygen site-directed mutagenesis SK-N-MC cells Solid Phase Synthesis solid-phase peptide synthesis species-selectivity Spezies-Selektivität Sphingolipide sphingolipids Sphingolipidstoffwechsel SPN (Synthetic preparation) SPPS spreading factor squaramide stability steady-state GTPase assay Streptococcus agalactiae structure in relation to) structure-activity relationship Structure-activity relationship (antitumor prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Antitumor agents Conformation Human Mammary gland (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Estrogen receptors Role: BSU (Biological study Structure-activity relationship (carboplatin derivs. with superior antitumor activity compared to the parent compd.) Structure-activity relationships Structure-based design Struktur-Aktivitäts-Beziehung Struktur-Wirkungs-Beziehungen subunit assembly of) sulphated oligosaccharide Synhtesis Syntaxin 13 synthesis Targeted drug delivery Tariquidar Taxol Test thermophilic microorganism in relation to) THU (Therapeutic use) TmHU TNM toll-like receptor Toll-like Rezeptoren transcriptional regulation Transfektion Transferrin Transferrinrezeptor Transition metal complexes Role: BAC (Biological activity or effector tumor Tumor Necrosis Factor-alpha: ME Tumor-Nekrose-Faktor Tumorantigen Tumorimmunologie Tumorzelle ulcerative colitis unclassified) UR-PI376 UR-PI97 UR-RG98 USES (Uses) (platinum complexes prepn. of water-sol. platinum porphyrin amine complexes with high tumor selectivity for use in photodynamic therapy) UV spectroscopy Vaccination Vektor <Genetik> viability in relation to) Vinblastine vinblastine hyaluronidase interaction melanoma inhibition viral vector virtual screening Vitamin C derivatives Vitamin C-Derivate Wang resin water soly. weighted field fit Wirkstoff Wirkstoff-Rezeptor-Bindung Wistar xenografts Glioblastom Xenotransplantate Y Rezeptor Y1 agonist Y1 antagonist Y1 receptor Y1 receptor antagonist Y1 Rezeptor Y1-Rezeptorantagonist Y1R antagonism Y1R binding Y2 receptor Y2 receptor antagonists Y2 Rezeptor Zelldifferenzierung Zirkulardichroismus Zymography Östrogene Östrogenrezeptor β2-adrenergic receptor
Number of items at this level: 460.

(+)-(s)-acetylmandelic acid

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

(acetoxyphenyl)indene deriv. binding by

Schneider, Martin R. and von Angerer, Erwin and Schönenberger, Helmut (1982) 5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound. European journal of medicinal chemistry 17 (3), pp. 245-248.

*Brain Ischemia: DT

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

*Brain Ischemia: EN

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

*Chemistry

Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2008) Frontiers in medicinal chemistry in Regensburg. ChemMedChem 3 (8), pp. 1181-1184.

*Enzyme Inhibitors: PD

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

*Matrix Metalloproteinases: AI

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

0 (Enzyme Inhibitors)

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

0 (Tumor Necrosis Factor-alpha)

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

1-(2

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

1-dicarboxylato]platinum(II)

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

15-Lipoxygenase

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

2

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) Amines Role: BAC (Biological activity or effector

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) Antitumor agents (prepn. and stereoselectivity in antitumor activity of [1

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) platinum diaminophenylpropane chloro prepn antitumor activity stereoselectivity antitumor activity platinum diaminophenylpropane chloro phenylpropanediamine platinum chloro prepn antitumor activity diamine platinum chloro prepn antitumor activity conformation platinum diaminophenylpropane chloro isomer

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

2-Guanidinothiazole

Wolf, Cornelia and Schulze, Frank R. and Buschauer, Armin and Schunack, Walter (1998) Combined histamine H_1/H_2 receptor antagonists: Part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures,. European Journal of Pharmaceutical Sciences 6 (3), pp. 187-196.

3

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

3-lactone

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

3D-QSAR

Dove, Stefan and Buschauer, Armin (1998) Imidazolylpropylguanidines as histamine H_2 receptor agonists: 3D-QSAR of a large series. Pharm. Acta Helv. 73 (3), pp. 145-155.

4

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

6-dic Structure-activity relationship (antitumor [Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-Dichloro-4-hydroxyphenyl)-2-phenylethanes

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Antitumor agents (mammary gland [Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) antitumor breast phenylethylenediamine platinum complex

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Estrogens Role: BAC (Biological activity or effector

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Mammary gland (neoplasm

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-tetra-O-acetyl--D-glucopyranosyl isothiocyanate

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

6-tetra-O-acetyl-1-thio--D-glucopyranoside

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

a novel

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

a(2a) adenosine receptor crystal-structure amino-acid beta(2)-adrenergic receptor structural instability adrenergic-receptor guinea-pig activation rhodopsin state

Schneider, Erich H. and Schnell, David and Strasser, Andrea and Dove, Stefan and Seifert, Roland (2010) Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor. Journal of Pharmacology and Experimental Therapeutics 333 (2), pp. 382-392.

ABC transporter

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

Kühnle, Matthias and Egger, Michael and Müller, Christine and Mahringer, Anne and Bernhardt, Günther and Fricker, Gert and König, Burkhard and Buschauer, Armin (2009) Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. Journal of Medicinal Chemistry 52 (4), pp. 1190-1197.

ABC-Transporter

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

ABCA1

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg

ABCB1

Ochoa Puentes, Cristian and Höcherl, Peter and Kühnle, Matthias and Bauer, Stefanie and Kürger, Kira and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2). Bioorganic & Medicinal Chemistry Letters 21 (12), pp. 3654-3657.

Kühnle, Matthias and Egger, Michael and Müller, Christine and Mahringer, Anne and Bernhardt, Günther and Fricker, Gert and König, Burkhard and Buschauer, Armin (2009) Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. Journal of Medicinal Chemistry 52 (4), pp. 1190-1197.

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

ABCG2

Ochoa Puentes, Cristian and Höcherl, Peter and Kühnle, Matthias and Bauer, Stefanie and Kürger, Kira and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2). Bioorganic & Medicinal Chemistry Letters 21 (12), pp. 3654-3657.

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg

Kühnle, Matthias and Egger, Michael and Müller, Christine and Mahringer, Anne and Bernhardt, Günther and Fricker, Gert and König, Burkhard and Buschauer, Armin (2009) Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. Journal of Medicinal Chemistry 52 (4), pp. 1190-1197.

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Acyl guanidines

Weiss, Stefan and Keller, Max and Bernhardt, G. and Buschauer, Armin and König, Burkhard (2010) N(G)-Acyl-argininamides as NPY Y (1) receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity. Bioorganic & Medicinal Chemistry (18), pp. 6292-6304.

Acylation

Weiss, Stefan and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Synthesis and characterization of DMAP-Modified NPY Y1 receptor antagonists as acyl-transfer catalysts. Collection of Czechoslovak chemical communications 76 (6), 763 -780.

Acylgruppe

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Acylguanidin

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Acylguanidine

Birnkammer, Tobias and Spickenreither, Anja and Brunskole, Irena and Lopuch, Miroslaw and Kagermeier, Nicole and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2012) The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. Journal of Medicinal Chemistry 55 (3), pp. 1147-1160.

Birnkammer, Tobias (2011) Highly potent and selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships of mono- and bivalent ligands. PhD, Universität Regensburg

Pluym, Nikola and Brennauer, Albert and Keller, Max and Ziemek, Ralf and Pop, Nathalie and Bernhardt, Günther and Buschauer, Armin (2011) Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists. ChemMedChem 6 (9), pp. 1727-1738.

Ghorai, Prasanta and Kraus, Anja and Birnkammer, Tobias and Geyer, Roland and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2010) Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.

Igel, Patrick and Geyer, Roland and Straßer, Andrea and Dove, Stefan and Seifert, Roland and Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), pp. 6297-6313.

Igel, Patrick and Schnell, David and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), pp. 225-231.

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Ghorai, Prasanta and Kraus, Anja and Keller, Max and Götte, Carsten and Igel, Patrick and Schneider, Erich and Schnell, David and Bernhardt, Günther and Dove, Stefan and Zabel, Manfred and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.

acylguanidines

Igel, Patrick and Dove, Stefan and Buschauer, Armin (2010) Histamine H4 receptor agonists. Bioorganic & Medicinal Chemistry Letters 20 (24), pp. 7191-7199.

Kraus, Anja and Ghorai, Prasanta and Birnkammer, Tobias and Schnell, David and Elz, Sigurd and Seifert, Roland and Dove, Stefan and Bernhardt, Günther and Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), pp. 232-240.

Brennauer, Albert and Keller, Max and Freund, Matthias and Bernhardt, Günther and Buschauer, Armin (2007) Decomposition of 1-(w-aminoalkanoyl)guanidines under alkaline conditions. Tetrahedron Letters 48 (39), pp. 6996-6999.

ADAM Proteins

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Adenylyl cyclase

Bischoff, Andrea and Püttmann, Kristina and Kötting, Annette and Moser, Christiane and Buschauer, Armin and Michel, Martin C. (2001) Limited signal transduction repertoire of human Y_5 neuropeptide Y receptors expressed in HEC-B cells. Peptides 22 (3), pp. 387-394.

Adenylyl cyclase . Bacillus anthracis . Edema factor .MANT nucleotide . Molecular modelling . Fluorescence spectroscopy

Taha, Hesham and Dove, Stefan and Geduhn, Jens and König, Burkhard and Shen, Yuequan and Tang, Wei-Jen and Seifert, Roland (2012) Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 monoand bis-(M)ANT-substituted nucleoside 5′-triphosphates. Naunyn-Schmiedeberg's Archives of Pharmacology (385), pp. 57-68.

Aequorin

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Ziemek, Ralf and Schneider, Erich and Kraus, Anja and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2007) Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence. Journal of Receptors and Signal Transduction 27 (4), pp. 217-233.

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

Ziemek, Ralf and Brennauer, Albert and Schneider, Erich and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2006) Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y(2) receptor ligands. European Journal of Pharmacology 551 (1-3), pp. 10-8.

Affymetrix gene chips

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg

Agonist

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

Akute myeloische Leukämie

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

alignment rules

Dove, Stefan and Buschauer, Armin (1999) Improved Alignment by Weighted Field Fit in CoMFA of Histamine H_2 Receptor Agonistic Imidazolylpropylguanidines. Quant. Struct.-Act. Relat. 18 (4), pp. 329-341.

ALR

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Amide

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

Amino acids Role: RCT (Reactant)

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

Aminothiazol

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

aminothiazole

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Antitumor agents (mammary gland prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Mammary gland (neoplasm

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Solubility (water soly. of platinum fluorophenylethylenediamine dicarboxylato complexes) fluorophenylethylenediamine dicarboxylato platinum complex prepn antitumor activity platinum fluorophenylethylenediamine dicarboxylato complex soly fluorophenylethylenediamine dicarboxylato platinum complex nucleophilic substitution kinetics fluorophenylethylenediamine dicarboxylatoplatinum complex

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II)

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Animal

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Animals

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Antagonist

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Weiss, Stefan and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Synthesis and characterization of DMAP-Modified NPY Y1 receptor antagonists as acyl-transfer catalysts. Collection of Czechoslovak chemical communications 76 (6), 763 -780.

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

antagonists & inhibitors

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Antiestrogen

Zimmermann, Jochen and Angerer, Erwin von (2007) Estrogenic and antiestrogenic activities of 2,4-diphenylfuran-based ligands of estrogen receptors α and β. The Journal of Steroid Biochemistry and Molecular Biology 104 (3-5), pp. 259-268.

Antiestrogene

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Antiestrogens

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

antigen

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

antimicrobials / hyaluronidase / molecular mechanism / pneumococci / spreading factor

Rigden, Daniel J. and Botzki, Alexander and Nukui, Masatoshi and Mewbourne, R. Brandon and Lamani, Ejvis and Braun, Stephan and von Angerer, Erwin and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin and Jedrzejas, Mark J. (2006) Design of new benzoxazole-2-thione derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole. Glycobiology 16 (8), pp. 757-765.

antitumor activity platinum chloro aminoethoxyestrone aminoethoxyestradiol

Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.

antitumor activity platinum fluorophenylethylenediamine complex platinum fluorophenylethylenediamine diastereoisomer complex ethylenediamine fluorophenyl platinum diastereoisomer complex

Mueller, Richard and Gust, Ronald and Jennerwein, Margaretha and Reile, Herta and Laske, Reiner and Krischke, Walter and Bernhardt, Günther and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1989) Tumor inhibiting [1,2-bis(fluorophenylethylenediamine]platinum(II) complexes. Part I. Synthesis. European Journal of Medicinal Chemistry 24 (4), pp. 341-348.

Antitumor agents

Bernhardt, Günther and Brunner, Henri and Gruber, Nick and Lottner, Christian and Pushpan, Simi K. and Tsuno, Takashi and Zabel, Manfred (2004) Carboplatin derivatives with superior antitumor activity compared to the parent compound. Inorganica Chimica Acta 357 (15), pp. 4452-4466.

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

Antitumor agents ([rac-1

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Antitumor agents (brain hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors)

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

Antitumor agents (mammary gland platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) Mammary gland (neoplasm

Gust, Ronald and Heinrich, Heike and Krauser, Rudolf and Schönenberger, Helmut (1999) [Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities. Inorganica chimica acta 285 (2), pp. 184-189.

antitumor effect)

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

antitumor vinblastine hyaluronidase interaction

Spruss, Thilo and Bernhardt, Günther (1996) Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy. In: Arnold, Wolfgang, (ed.) Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology, 51. UNSPECIFIED, pp. 145-150.

Antiöstrogene

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Apo-E

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Apoenzym

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Apolipoprotein A

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Apoptosis

Kießling, Stephan (2002) Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors alpha in humanen Kolonepithelzellen. PhD, Universität Regensburg

Aralkylgruppe

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Argininamid

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

Argininamid BIBP 3226

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

argininamide

Pluym, Nikola and Brennauer, Albert and Keller, Max and Ziemek, Ralf and Pop, Nathalie and Bernhardt, Günther and Buschauer, Armin (2011) Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists. ChemMedChem 6 (9), pp. 1727-1738.

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

argininamide BIBP 3226

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

argininamide derivatives

Keller, Max and Erdmann, Daniela and Teng, Shangjun and Pop, Nathalie and Pluym, Nikola and Bernhardt, Günther and Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), pp. 2859-2878.

argininamides

Weiss, Stefan and Keller, Max and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), pp. 9858-9866.

Argininderivate

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

arpromidine

Ghorai, Prasanta and Kraus, Anja and Keller, Max and Götte, Carsten and Igel, Patrick and Schneider, Erich and Schnell, David and Bernhardt, Günther and Dove, Stefan and Zabel, Manfred and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.

Xie, Sheng-Xue and Schalkhausser, Fabian and Ye, Qi-Zhuang and Seifert, Roland and Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), pp. 9-16.

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

Schuster, Andreas and Bernhardt, Günther and Eibler, Ernst and Buschauer, Armin and Hesselink, Willy (1998) Chiral separation of 3-phenyl-3-(2-pyridyl)propylamines, and analogous guanidines and guanidine-N-carboxylic acid esters with HPLC and CZE. Journal of Chromatography A 793 (1), pp. 77-90.

Arteriosklerose

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg

arylbenzimidazoles

Igel, Patrick and Dove, Stefan and Buschauer, Armin (2010) Histamine H4 receptor agonists. Bioorganic & Medicinal Chemistry Letters 20 (24), pp. 7191-7199.

ascorbic acid derivatives

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Spickenreither, Martin and Braun, Stephan and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2006) Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorganic & Medicinal Chemistry Letters 16 (20), pp. 5313-5316.

Assay

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

assays

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

at high temp. and pressure

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

atherosclerosis

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

Atherosklerose

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

autoradiography

Keller, Max and Pop, Nathalie and Hutzler, Christoph and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2008) Guanidine - acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. Journal of Medicinal Chemistry 51 (24), pp. 8168-8172.

Bacteria (thermophilic

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

BCNU

Vogelhuber, Werner and Spruß, Thilo and Bernhardt, Günther and Buschauer, Armin and Göpferich, Achim (2002) Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts,. International Journal of Pharmaceutics 238 (1-2), pp. 111-121.

BCRP

Kühnle, Matthias and Egger, Michael and Müller, Christine and Mahringer, Anne and Bernhardt, Günther and Fricker, Gert and König, Burkhard and Buschauer, Armin (2009) Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. Journal of Medicinal Chemistry 52 (4), pp. 1190-1197.

bee venom hyaluronidase

Salmen, Sunnhild and Hoechstetter, Julia and Käsbauer, Christian and Paper, Dieter H. and Bernhardt, Günther and Buschauer, Armin (2005) Sulphated Oligosaccharides as Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus agalactiae. Planta Med. 71, pp. 727-732.

Benzimidazole-2-thiones

Braun, Stephan and Botzki, Alexander and Salmen, Sunnhild and Textor, Christian and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2011) Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase. European Journal of Medicinal Chemistry 46 (9), pp. 4419-4429.

Benzoxazol-2-thion

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg

benzoxazole-2-thione

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg

Benzoxazole-2-thiones

Braun, Stephan and Botzki, Alexander and Salmen, Sunnhild and Textor, Christian and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2011) Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase. European Journal of Medicinal Chemistry 46 (9), pp. 4419-4429.

beta-arrestins

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

beta2-syntrophin

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg

BIBP 3226

Weiss, Stefan and Keller, Max and Bernhardt, G. and Buschauer, Armin and König, Burkhard (2010) N(G)-Acyl-argininamides as NPY Y (1) receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity. Bioorganic & Medicinal Chemistry (18), pp. 6292-6304.

Keller, Max and Pop, Nathalie and Hutzler, Christoph and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2008) Guanidine - acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. Journal of Medicinal Chemistry 51 (24), pp. 8168-8172.

Weiss, Stefan and Keller, Max and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), pp. 9858-9866.

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

BIIE 0246

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

BIIE0246

Ziemek, Ralf and Brennauer, Albert and Schneider, Erich and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2006) Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y(2) receptor ligands. European Journal of Pharmacology 551 (1-3), pp. 10-8.

binding affinity

Schneider, Erich and Mayer, Matthias and Ziemek, Ralf and Li, Liantao and Hutzler, Christoph and Bernhardt, Günther and Buschauer, Armin (2006) A Simple and Powerful Flow Cytometric Method for the Simultaneous Determination of Multiple Parameters at G-Protein-coupled Receptor Subtypes. ChemBioChem 7 (9), pp. 1400-1409.

Biodegradable polymer

Vogelhuber, Werner and Spruß, Thilo and Bernhardt, Günther and Buschauer, Armin and Göpferich, Achim (2002) Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts,. International Journal of Pharmaceutics 238 (1-2), pp. 111-121.

Vogelhuber, W. and Rutunno, P. and Magni, E. and Gazzaniga, A. and Spruss, Thilo and Bernhardt, Günther and Buschauer, Armin and Goepferich, Achim (2001) Programmable biodegradable implants. Journal of Controlled Release 73 (1), pp. 75-88.

Bioisostere

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

bioisosteric replacement

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Bioisosterie

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

bioisosterism

Pluym, Nikola and Brennauer, Albert and Keller, Max and Ziemek, Ralf and Pop, Nathalie and Bernhardt, Günther and Buschauer, Armin (2011) Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists. ChemMedChem 6 (9), pp. 1727-1738.

Kraus, Anja and Ghorai, Prasanta and Birnkammer, Tobias and Schnell, David and Elz, Sigurd and Seifert, Roland and Dove, Stefan and Bernhardt, Günther and Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), pp. 232-240.

bioisoterism

Ghorai, Prasanta and Kraus, Anja and Keller, Max and Götte, Carsten and Igel, Patrick and Schneider, Erich and Schnell, David and Bernhardt, Günther and Dove, Stefan and Zabel, Manfred and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.

BIOL (Biological study)

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

BIOL (Biological study) (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) platinum chloro fluorohydroxyphenylethylenediamine prepn antitumor breast cancer

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (2005) [N-Ethyl- and [N,N'-Diethyl-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): Structure and Cytotoxic/Estrogenic Activity in Breast Cancer Cells. Journal of Medicinal Chemistry 48 (23), pp. 7132-7144.

biological response modifiers

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

Biologische Aktivität

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

biscycloalkylamineplatinum dichloro antitumor prepn structure

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

bivalent ligand

Birnkammer, Tobias and Spickenreither, Anja and Brunskole, Irena and Lopuch, Miroslaw and Kagermeier, Nicole and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2012) The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. Journal of Medicinal Chemistry 55 (3), pp. 1147-1160.

Birnkammer, Tobias (2011) Highly potent and selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships of mono- and bivalent ligands. PhD, Universität Regensburg

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

bivalent ligands

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

Weiss, Stefan and Keller, Max and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), pp. 9858-9866.

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

Bivalente Liganden

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

bivalenter Ligand

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Bladder

Bernhardt, Günther and Brunner, Henri and Gruber, Nick and Lottner, Christian and Pushpan, Simi K. and Tsuno, Takashi and Zabel, Manfred (2004) Carboplatin derivatives with superior antitumor activity compared to the parent compound. Inorganica Chimica Acta 357 (15), pp. 4452-4466.

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

blood-brain barrier

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

Blut

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

Blut-Hirn-Schranke

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

BODIPY

Xie, Sheng-Xue and Petrache, Georgiana and Schneider, Erich and Ye, Qi-Zhuang and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorganic & Medicinal Chemistry Letters 16 (15), pp. 3886-3890.

Bovine testicular hyaluronidase

Spickenreither, Martin and Braun, Stephan and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2006) Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorganic & Medicinal Chemistry Letters 16 (20), pp. 5313-5316.

Salmen, Sunnhild and Hoechstetter, Julia and Käsbauer, Christian and Paper, Dieter H. and Bernhardt, Günther and Buschauer, Armin (2005) Sulphated Oligosaccharides as Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus agalactiae. Planta Med. 71, pp. 727-732.

Oettl, Martin and Hoechstetter, Julia and Asen, Iris and Bernhardt, Günther and Buschauer, Armin (2003) Comparative characterization of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae in pharmaceutical preparations. European Journal of Pharmaceutical Sciences 18 (3-4), pp. 267-277.

bovine testikuläre Hyaluronidase

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

BPR (Biological process)

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Brain

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

Brain cancer

Vogelhuber, W. and Rutunno, P. and Magni, E. and Gazzaniga, A. and Spruss, Thilo and Bernhardt, Günther and Buschauer, Armin and Goepferich, Achim (2001) Programmable biodegradable implants. Journal of Controlled Release 73 (1), pp. 75-88.

brain tumors

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

breast cancer cells

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

bridging ligands

Keller, Max and Teng, Shangjun and Bernhardt, Günther and Buschauer, Armin (2009) Bivalent argininamide-type neuropeptide Y Y1 antagonists do not support the hypothesis of receptor dimerisation. ChemMedChem 4 (10), pp. 1733-1745.

Brustkrebs

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Brustkrebszellen

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

BSU (Biological study

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

Buoyant density separation

Parker, Steven L. and Parker, Michael S. and Buschauer, Armin and Balasubramaniam, Ambikaipakan (2003) Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides. European Journal of Pharmacology 474 (1), pp. 31-42.

Calcein-AM

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Calcium

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Bischoff, Andrea and Püttmann, Kristina and Kötting, Annette and Moser, Christiane and Buschauer, Armin and Michel, Martin C. (2001) Limited signal transduction repertoire of human Y_5 neuropeptide Y receptors expressed in HEC-B cells. Peptides 22 (3), pp. 387-394.

Calcium Assay

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

calcium mobilization

Schneider, Erich and Mayer, Matthias and Ziemek, Ralf and Li, Liantao and Hutzler, Christoph and Bernhardt, Günther and Buschauer, Armin (2006) A Simple and Powerful Flow Cytometric Method for the Simultaneous Determination of Multiple Parameters at G-Protein-coupled Receptor Subtypes. ChemBioChem 7 (9), pp. 1400-1409.

cancer

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

carboplatin deriv anticancer

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

carboplatin deriv prepn

Bernhardt, Günther and Brunner, Henri and Gruber, Nick and Lottner, Christian and Pushpan, Simi K. and Tsuno, Takashi and Zabel, Manfred (2004) Carboplatin derivatives with superior antitumor activity compared to the parent compound. Inorganica Chimica Acta 357 (15), pp. 4452-4466.

carboplatin derivs. with superior antitumor activity compared to the parent compd.)

Bernhardt, Günther and Brunner, Henri and Gruber, Nick and Lottner, Christian and Pushpan, Simi K. and Tsuno, Takashi and Zabel, Manfred (2004) Carboplatin derivatives with superior antitumor activity compared to the parent compound. Inorganica Chimica Acta 357 (15), pp. 4452-4466.

carcinoma

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Cardiotonics

Dove, Stefan and Buschauer, Armin (1998) Imidazolylpropylguanidines as histamine H_2 receptor agonists: 3D-QSAR of a large series. Pharm. Acta Helv. 73 (3), pp. 145-155.

CD-Spektroskopie

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

cell surface

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Chaotropic agent

Parker, S.L. and Parker, M. S. and Lundell, I. and Balasubramaniam, A. and Buschauer, Armin and Kane, J. K. and Yalcin, A. and Berglund, M. M. (2002) Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling. Regulatory Peptides 107 (1-3), pp. 49-62.

Chemie

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

Chemische Synthese

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

Colombo, Noemi (2007) Synthesis and conformational analysis of polypeptides related to the inhibitor of the DNA binding and cell differentiation Id2. PhD, Universität Regensburg

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

chemosensitivity human melanoma cell cytostatic

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion)

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy)

Spruss, Thilo and Bernhardt, Günther (1996) Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy. In: Arnold, Wolfgang, (ed.) Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology, 51. UNSPECIFIED, pp. 145-150.

Chemotaxis

Reher, Till M. and Neumann, Detlef and Buschauer, Armin and Seifert, Roland (2012) Incomplete activation of human eosinophils via the histamine H(4)-receptor: Evidence for ligand-specific receptor conformations. Biochemical Pharmacology 84 (2), pp. 192-203.

Chemotherapie

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

child brain tumor chemotherapy hyaluronidase combination

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

Chimeric G protein

Ziemek, Ralf and Schneider, Erich and Kraus, Anja and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2007) Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence. Journal of Receptors and Signal Transduction 27 (4), pp. 217-233.

Ziemek, Ralf and Brennauer, Albert and Schneider, Erich and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2006) Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y(2) receptor ligands. European Journal of Pharmacology 551 (1-3), pp. 10-8.

chimeric G-protein

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

chimeric receptors

Brunskole, Irena and Strasser, Andrea and Seifert, Roland and Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), pp. 301-317.

chimäres G-Protein

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

chiral

Ghorai, Prasanta and Kraus, Anja and Birnkammer, Tobias and Geyer, Roland and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2010) Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.

chiral HPLC

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Cholesterinstoffwechsel

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

circular dichroism

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

clozapine analogues

Igel, Patrick and Dove, Stefan and Buschauer, Armin (2010) Histamine H4 receptor agonists. Bioorganic & Medicinal Chemistry Letters 20 (24), pp. 7191-7199.

Colitis ulcerosa

Stopfer, Peter (2003) Biologische Wirkungen der Aktivierung des Lymphotoxin-beta-Rezeptors. PhD, Universität Regensburg

colon

Kießling, Stephan (2002) Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors alpha in humanen Kolonepithelzellen. PhD, Universität Regensburg

Colorectal carcinoma

Weiss, Thomas S. and Bernhardt, Günther and Buschauer, Armin and Thasler, Wolfgang E. and Dolgner, Doris and Zirngibl, Hubert and Jauch, Karl-Walter (2002) Polyamine levels of human colorectal adenocarcinomas are correlate with tumor stage and grade,. International Journal of Colorectal Disease 17 (6), pp. 381-387.

CoMFA

Dove, Stefan and Buschauer, Armin (1999) Improved Alignment by Weighted Field Fit in CoMFA of Histamine H_2 Receptor Agonistic Imidazolylpropylguanidines. Quant. Struct.-Act. Relat. 18 (4), pp. 329-341.

Dove, Stefan and Buschauer, Armin (1998) Imidazolylpropylguanidines as histamine H_2 receptor agonists: 3D-QSAR of a large series. Pharm. Acta Helv. 73 (3), pp. 145-155.

complement C1q C-chain

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

composition (lactate dehydrogenase of

Bernhardt, Günther and Rudolph, Rainer and Jaenicke, Rainer (1981) Reassociation of lactic dehydrogenase from pig heart studied by cross-linking with glutaraldehyde. Zeitschrift fuer Naturforschung, C Journal of Biosciences 36C (9-10), pp. 772-777.

confocal microscopy

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

Keller, Max and Erdmann, Daniela and Teng, Shangjun and Pop, Nathalie and Pluym, Nikola and Bernhardt, Günther and Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), pp. 2859-2878.

confocal miroscopy

Pluym, Nikola (2011) Application of the guanidine–acylguanidine bioisosteric approach to NPY Y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools. PhD, Universität Regensburg

Conformation Stereochemistry (antitumor potency of diastereomeric and enantiomeric platinum diaminophenylpropane dichloro complexes in relation to) Structure-activity relationship (antitumor stereoselectivity of antitumor active [1

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

conformational restriction

Geyer, Roland and Buschauer, Armin (2011) Synthesis and histamine H3 and H4 receptor activity of conformationally restricted cyanoguanidines related to UR-PI376. Archiv der Pharmazie 344 (12), pp. 775-785.

constitutive activity

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Cope rearrangement (of bis(hydroxyphenyl)ethylenediamine reaction products with fluorobenzaldehyde)

Mueller, Richard and Gust, Ronald and Jennerwein, Margaretha and Reile, Herta and Laske, Reiner and Krischke, Walter and Bernhardt, Günther and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1989) Tumor inhibiting [1,2-bis(fluorophenylethylenediamine]platinum(II) complexes. Part I. Synthesis. European Journal of Medicinal Chemistry 24 (4), pp. 341-348.

Coumarin

Maucher, A. and Kager, M. and Angerer, E. von (1993) Evaluation of the antitumour activity of coumarin in prostate cancer models. Journal of cancer research and clinical oncology 119 (3), pp. 150-154.

CpG-Methylierung

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

CRE

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Cross-coupling

Egger, Michael and Li, Xuqin and Müller, Christine and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2007) Tariquidar analogues: synthesis by Cu(I)-catalysed N/O–aryl coupling and inhibitory activity against the ABCB1 transporter. European Journal of Organic Chemistry 2007 (16), pp. 2643-2649.

Cyanine

Xie, Sheng-Xue and Petrache, Georgiana and Schneider, Erich and Ye, Qi-Zhuang and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorganic & Medicinal Chemistry Letters 16 (15), pp. 3886-3890.

Cyanoguanidin

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

cyanoguanidine

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Igel, Patrick and Geyer, Roland and Straßer, Andrea and Dove, Stefan and Seifert, Roland and Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), pp. 6297-6313.

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

cyanoguanidines

Geyer, Roland and Buschauer, Armin (2011) Synthesis and histamine H3 and H4 receptor activity of conformationally restricted cyanoguanidines related to UR-PI376. Archiv der Pharmazie 344 (12), pp. 775-785.

Igel, Patrick and Dove, Stefan and Buschauer, Armin (2010) Histamine H4 receptor agonists. Bioorganic & Medicinal Chemistry Letters 20 (24), pp. 7191-7199.

cycloaddition

Weiss, Stefan and Keller, Max and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), pp. 9858-9866.

cyclobond

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

cyclodextrins

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

Cytokin

Kießling, Stephan (2002) Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors alpha in humanen Kolonepithelzellen. PhD, Universität Regensburg

cytotoxicity

Kühnle, Matthias and Egger, Michael and Müller, Christine and Mahringer, Anne and Bernhardt, Günther and Fricker, Gert and König, Burkhard and Buschauer, Armin (2009) Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. Journal of Medicinal Chemistry 52 (4), pp. 1190-1197.

Darmkrebs

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

decay kinetics adjustment

Posavec, Damir (2011) Adjustment of the decay kinetics of photogenerated endoperoxides embedded in various carrier materials aiming at medical applications. PhD, Universität Regensburg

Degradation rate

Brennauer, Albert and Keller, Max and Freund, Matthias and Bernhardt, Günther and Buschauer, Armin (2007) Decomposition of 1-(w-aminoalkanoyl)guanidines under alkaline conditions. Tetrahedron Letters 48 (39), pp. 6996-6999.

Dendritische Zelle

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

Deoxyribonucleic acids Role: BPR (Biological process)

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

Dephosphorylatin

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

Development (child

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

diastereomeric derivatives

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

dichlorobis(cycloalkylamine)platinum(II) complexes as

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

dichlorobiscycloalkylamineplatinum antitumor prepn structure

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Differentielle Genexpression

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg

dimerisation

Keller, Max and Teng, Shangjun and Bernhardt, Günther and Buschauer, Armin (2009) Bivalent argininamide-type neuropeptide Y Y1 antagonists do not support the hypothesis of receptor dimerisation. ChemMedChem 4 (10), pp. 1733-1745.

Diphenylfuran

Zimmermann, Jochen and Angerer, Erwin von (2007) Estrogenic and antiestrogenic activities of 2,4-diphenylfuran-based ligands of estrogen receptors α and β. The Journal of Steroid Biochemistry and Molecular Biology 104 (3-5), pp. 259-268.

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

DNA formation ([Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

DNS-Bindung

Colombo, Noemi (2007) Synthesis and conformational analysis of polypeptides related to the inhibitor of the DNA binding and cell differentiation Id2. PhD, Universität Regensburg

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

Doxorubicin

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Doxorubicin-Nanopartikel

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Drosophila Schneider-2 Zellen

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Drug distribution

Muckenschnabel, I. and Bernhardt, Günther and Spruß, Thilo and Buschauer, Armin (1998) Pharmacokinetics and tissue distribution of bovine testicular hyaluronidase and vinblastine in mice: an attempt to optimize the mode of adjuvant hyaluronidase administration in cancer chemotherapy. Cancer Letters 131 (1), pp. 71-84.

Drug interactions (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy)

Spruss, Thilo and Bernhardt, Günther (1996) Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy. In: Arnold, Wolfgang, (ed.) Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology, 51. UNSPECIFIED, pp. 145-150.

drug therapy

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Dunning R3327-G tumour

Maucher, A. and Angerer, E. von (1993) Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours. Journal of cancer research and clinical oncology 119 (11), pp. 669-674.

Maucher, A. and Kager, M. and Angerer, E. von (1993) Evaluation of the antitumour activity of coumarin in prostate cancer models. Journal of cancer research and clinical oncology 119 (3), pp. 150-154.

Dunning R3327-MatLu tumour

Maucher, A. and Kager, M. and Angerer, E. von (1993) Evaluation of the antitumour activity of coumarin in prostate cancer models. Journal of cancer research and clinical oncology 119 (3), pp. 150-154.

Durchflusscytometrie

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Durchflusszytometrie

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

E-LDL

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

EC 3.4.24.- (ADAM Proteins)

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

EC 3.4.24.- (Matrix Metalloproteinases)

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

EC 3.4.24.- (Metalloendopeptidases)

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

EC 3.4.24.- (tumor necrosis factor-alpha convertase)

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

EC 3.4.24.24 (Matrix Metalloproteinase 2)

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

EC 3.4.24.35 (Matrix Metalloproteinase 9)

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Einschlusskörper

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Elacridar

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Elektronensprayionisations-Massenspektrometrie

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

enantiomers

Ghorai, Prasanta and Kraus, Anja and Birnkammer, Tobias and Geyer, Roland and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2010) Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.

Endocrine therapy

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Endocytosis rate

Parker, Steven L. and Parker, Michael S. and Buschauer, Armin and Balasubramaniam, Ambikaipakan (2003) Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides. European Journal of Pharmacology 474 (1), pp. 31-42.

Endokrine Therapie

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

endoperoxides

Posavec, Damir (2011) Adjustment of the decay kinetics of photogenerated endoperoxides embedded in various carrier materials aiming at medical applications. PhD, Universität Regensburg

Endosomal sorting

Parker, Steven L. and Parker, Michael S. and Buschauer, Armin and Balasubramaniam, Ambikaipakan (2003) Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides. European Journal of Pharmacology 474 (1), pp. 31-42.

Endosome

Parker, S.L. and Parker, M. S. and Lundell, I. and Balasubramaniam, A. and Buschauer, Armin and Kane, J. K. and Yalcin, A. and Berglund, M. M. (2002) Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling. Regulatory Peptides 107 (1-3), pp. 49-62.

Entzündung

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

enzyme inhibitor

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

Enzyminhibitor

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

Enzymologie

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

enzymology

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Eosinophils

Reher, Till M. and Neumann, Detlef and Buschauer, Armin and Seifert, Roland (2012) Incomplete activation of human eosinophils via the histamine H(4)-receptor: Evidence for ligand-specific receptor conformations. Biochemical Pharmacology 84 (2), pp. 192-203.

Epac

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Epithelzelle

Kießling, Stephan (2002) Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors alpha in humanen Kolonepithelzellen. PhD, Universität Regensburg

equilibrium

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

estradiol aminoethoxy platinum chloro

Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.

estrogen receptor

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

estrogen receptor affinity

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

estrogen receptor subtype

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Estrogen receptor β

Zimmermann, Jochen and Angerer, Erwin von (2007) Estrogenic and antiestrogenic activities of 2,4-diphenylfuran-based ligands of estrogen receptors α and β. The Journal of Steroid Biochemistry and Molecular Biology 104 (3-5), pp. 259-268.

Estrogen Rezeptor

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Estrogen Rezeptor Subtyp

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

estrogenic/antiestrogenic activity

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

estrone aminoethoxy platinum chloro

Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.

except adverse)

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

extracellular domains

Brunskole, Irena (2011) Molecular and cellular analysis of aminergic G protein-coupled receptors: histamine H2, H4 and β2-adrenergic receptors, a scientific paradigm. PhD, Universität Regensburg

extracellular loops

Brunskole, Irena and Strasser, Andrea and Seifert, Roland and Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), pp. 301-317.

Festphasenpeptidsynthese

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

Festphasensynthese

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

Festphasentechnik

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

Fever and Hyperthermia (chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion)

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

Fibroblast

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

flow cytometry

Pluym, Nikola (2011) Application of the guanidine–acylguanidine bioisosteric approach to NPY Y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools. PhD, Universität Regensburg

Keller, Max and Erdmann, Daniela and Teng, Shangjun and Pop, Nathalie and Pluym, Nikola and Bernhardt, Günther and Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), pp. 2859-2878.

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Ziemek, Ralf and Schneider, Erich and Kraus, Anja and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2007) Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence. Journal of Receptors and Signal Transduction 27 (4), pp. 217-233.

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

Schneider, Erich and Mayer, Matthias and Ziemek, Ralf and Li, Liantao and Hutzler, Christoph and Bernhardt, Günther and Buschauer, Armin (2006) A Simple and Powerful Flow Cytometric Method for the Simultaneous Determination of Multiple Parameters at G-Protein-coupled Receptor Subtypes. ChemBioChem 7 (9), pp. 1400-1409.

Ziemek, Ralf and Brennauer, Albert and Schneider, Erich and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2006) Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y(2) receptor ligands. European Journal of Pharmacology 551 (1-3), pp. 10-8.

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

fluorescence

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

fluorescence ligand

Pluym, Nikola (2011) Application of the guanidine–acylguanidine bioisosteric approach to NPY Y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools. PhD, Universität Regensburg

fluorescence spectroscopy

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

fluorescent ligand

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

fluorescent ligands

Keller, Max and Erdmann, Daniela and Teng, Shangjun and Pop, Nathalie and Pluym, Nikola and Bernhardt, Günther and Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), pp. 2859-2878.

Fluorescent probe

Ziemek, Ralf and Brennauer, Albert and Schneider, Erich and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2006) Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y(2) receptor ligands. European Journal of Pharmacology 551 (1-3), pp. 10-8.

fluorescent probes

Schneider, Erich and Mayer, Matthias and Ziemek, Ralf and Li, Liantao and Hutzler, Christoph and Bernhardt, Günther and Buschauer, Armin (2006) A Simple and Powerful Flow Cytometric Method for the Simultaneous Determination of Multiple Parameters at G-Protein-coupled Receptor Subtypes. ChemBioChem 7 (9), pp. 1400-1409.

Xie, Sheng-Xue and Petrache, Georgiana and Schneider, Erich and Ye, Qi-Zhuang and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorganic & Medicinal Chemistry Letters 16 (15), pp. 3886-3890.

fluorescent proteins

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

Fluoreszenz

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Fluoreszenz Mikroskopie

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg

Fluoreszenz-Resonanz-Energie-Transfer

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

Fluoreszenzligand

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Fluoreszenzspektroskopie

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

fluorimetric

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

Fluorimetrie

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

fluorimetrisch

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

fluorophenyl ethylendiamine cyclobutane carboxylatoplatinum synthesis anticancer

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

fluorophenylethylenediaminedichloroplatinum complex prepn stability neoplasm inhibition

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

foam cells

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

folate receptor beta

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

FORM (Formation

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

FRET

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Functional selectivity

Reher, Till M. and Neumann, Detlef and Buschauer, Armin and Seifert, Roland (2012) Incomplete activation of human eosinophils via the histamine H(4)-receptor: Evidence for ligand-specific receptor conformations. Biochemical Pharmacology 84 (2), pp. 192-203.

Fura-2

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Furanderivate

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Fusionsprotein

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

G protein coupled receptor

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

G protein regulation

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

G protein-coupled receptor

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

G-protein

Bischoff, Andrea and Püttmann, Kristina and Kötting, Annette and Moser, Christiane and Buschauer, Armin and Michel, Martin C. (2001) Limited signal transduction repertoire of human Y_5 neuropeptide Y receptors expressed in HEC-B cells. Peptides 22 (3), pp. 387-394.

G-protein coupled receptor

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

G-Protein gekoppelter Rezeptor

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

G-Protein-gekoppelter Rezeptor

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

Gastrointestinaler Tumor

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

gene therapy

Wieser, Carsten (2004) Herpesvirus saimiri basierte Vektoren für die somatische Gentherapie der Rheumatoiden Arthritis. PhD, Universität Regensburg

Genexpression

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

Genregulation

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Hähnel, Viola (2003) Die transkriptionelle Regulation der Toll-like Rezeptoren (TLR2, TLR3 und TLR4) in mononukleären Phagozyten. PhD, Universität Regensburg

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

Gentherapie

Wieser, Carsten (2004) Herpesvirus saimiri basierte Vektoren für die somatische Gentherapie der Rheumatoiden Arthritis. PhD, Universität Regensburg

Gi protein family

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

Gi/Go-proteins

Pop, Nathalie and Igel, Patrick and Brennauer, Albert and Cabrele, Chiara and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2011) Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells. Journal of Receptors and Signal Transduction 31 (4), pp. 271-285.

Glioblastom

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

glioblastoma

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

glucurono-6

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Glykosphingolipide

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Glykosylierung

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

GPCR

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Weiss, Stefan and Keller, Max and Bernhardt, G. and Buschauer, Armin and König, Burkhard (2010) N(G)-Acyl-argininamides as NPY Y (1) receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity. Bioorganic & Medicinal Chemistry (18), pp. 6292-6304.

GRKs

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

GTPase

Schnell, David and Brunskole, Irena and Ladova, Katerina and Schneider, Erich H. and Igel, Patrick and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470.

GTPase assay

Birnkammer, Tobias and Spickenreither, Anja and Brunskole, Irena and Lopuch, Miroslaw and Kagermeier, Nicole and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2012) The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. Journal of Medicinal Chemistry 55 (3), pp. 1147-1160.

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

Xie, Sheng-Xue and Petrache, Georgiana and Schneider, Erich and Ye, Qi-Zhuang and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorganic & Medicinal Chemistry Letters 16 (15), pp. 3886-3890.

GTPase-Assay

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

GTPyS

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Guanidin

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

Guanidinderivate

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

Guanidines

Xie, Sheng-Xue and Schalkhausser, Fabian and Ye, Qi-Zhuang and Seifert, Roland and Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), pp. 9-16.

Schuster, Andreas and Bernhardt, Günther and Eibler, Ernst and Buschauer, Armin and Hesselink, Willy (1998) Chiral separation of 3-phenyl-3-(2-pyridyl)propylamines, and analogous guanidines and guanidine-N-carboxylic acid esters with HPLC and CZE. Journal of Chromatography A 793 (1), pp. 77-90.

guanidinium compounds

Weiss, Stefan and Keller, Max and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), pp. 9858-9866.

guanidinylation

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Guanidinylierung

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

H2 receptor agonist

Ghorai, Prasanta and Kraus, Anja and Birnkammer, Tobias and Geyer, Roland and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2010) Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.

Ghorai, Prasanta and Kraus, Anja and Keller, Max and Götte, Carsten and Igel, Patrick and Schneider, Erich and Schnell, David and Bernhardt, Günther and Dove, Stefan and Zabel, Manfred and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.

h2 receptor agonists

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

h2 receptor antagonists

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

H2 receptor model

Ghorai, Prasanta and Kraus, Anja and Keller, Max and Götte, Carsten and Igel, Patrick and Schneider, Erich and Schnell, David and Bernhardt, Günther and Dove, Stefan and Zabel, Manfred and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.

H2-receptor

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

H2-Rezeptor

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

H3-receptor

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

H3-Rezeptor

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

H4 receptor

Geyer, Roland and Buschauer, Armin (2011) Synthesis and histamine H3 and H4 receptor activity of conformationally restricted cyanoguanidines related to UR-PI376. Archiv der Pharmazie 344 (12), pp. 775-785.

H4 receptor agonist

Ghorai, Prasanta and Kraus, Anja and Keller, Max and Götte, Carsten and Igel, Patrick and Schneider, Erich and Schnell, David and Bernhardt, Günther and Dove, Stefan and Zabel, Manfred and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.

H4 receptor selectivity

Igel, Patrick and Dove, Stefan and Buschauer, Armin (2010) Histamine H4 receptor agonists. Bioorganic & Medicinal Chemistry Letters 20 (24), pp. 7191-7199.

H4-receptor

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

H4-Rezeptor

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Hals-Nasen-Ohren-Tumor

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Heart

Bernhardt, Günther and Rudolph, Rainer and Jaenicke, Rainer (1981) Reassociation of lactic dehydrogenase from pig heart studied by cross-linking with glutaraldehyde. Zeitschrift fuer Naturforschung, C Journal of Biosciences 36C (9-10), pp. 772-777.

Heat (on biol. mols. and microorganisms)

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

heat thermophilic bacteria degrdn amino acid degrdn heat pressure peptide degrdn heat pressure

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

HEK293 cells

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

HEK293 Zellen

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Helix-loop-Helix

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

hematoporphyrin platinum amine prepn antitumor photodynamic therapy

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

Hep27 (DHRS2)

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

heparin

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

hepatocellular carcinoma

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Hepatozellular Karzinoma

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Herpesvirus saimiri

Wieser, Carsten (2004) Herpesvirus saimiri basierte Vektoren für die somatische Gentherapie der Rheumatoiden Arthritis. PhD, Universität Regensburg

Wieser, Carsten (2004) Herpesvirus saimiri basierte Vektoren für die somatische Gentherapie der Rheumatoiden Arthritis. PhD, Universität Regensburg

Heterocyclische Verbindungen

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

high temp. and pressure effect on amino acids of

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

High-density-Lipoproteine

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

highly active carboplatin deriv.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Hill slope

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

Hirnmetastase

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Hirntumor

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Histamin

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Histamin H2 Rezeptor Agonist

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

Histamin-H2-Rezeptor

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

histamine

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

Geyer, Roland and Buschauer, Armin (2011) Synthesis and histamine H3 and H4 receptor activity of conformationally restricted cyanoguanidines related to UR-PI376. Archiv der Pharmazie 344 (12), pp. 775-785.

Schnell, David and Brunskole, Irena and Ladova, Katerina and Schneider, Erich H. and Igel, Patrick and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470.

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Ghorai, Prasanta and Kraus, Anja and Birnkammer, Tobias and Geyer, Roland and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2010) Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.

Wolf, Cornelia and Schulze, Frank R. and Buschauer, Armin and Schunack, Walter (1998) Combined histamine H_1/H_2 receptor antagonists: Part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures,. European Journal of Pharmaceutical Sciences 6 (3), pp. 187-196.

Histamine agonists

Schuster, Andreas and Bernhardt, Günther and Eibler, Ernst and Buschauer, Armin and Hesselink, Willy (1998) Chiral separation of 3-phenyl-3-(2-pyridyl)propylamines, and analogous guanidines and guanidine-N-carboxylic acid esters with HPLC and CZE. Journal of Chromatography A 793 (1), pp. 77-90.

Histamine H1 receptor antagonists

Wolf, Cornelia and Schulze, Frank R. and Buschauer, Armin and Schunack, Walter (1998) Combined histamine H_1/H_2 receptor antagonists: Part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures,. European Journal of Pharmaceutical Sciences 6 (3), pp. 187-196.

histamine H2 receptor

Birnkammer, Tobias and Spickenreither, Anja and Brunskole, Irena and Lopuch, Miroslaw and Kagermeier, Nicole and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2012) The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. Journal of Medicinal Chemistry 55 (3), pp. 1147-1160.

Brunskole, Irena (2011) Molecular and cellular analysis of aminergic G protein-coupled receptors: histamine H2, H4 and β2-adrenergic receptors, a scientific paradigm. PhD, Universität Regensburg

Birnkammer, Tobias (2011) Highly potent and selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships of mono- and bivalent ligands. PhD, Universität Regensburg

Kraus, Anja and Ghorai, Prasanta and Birnkammer, Tobias and Schnell, David and Elz, Sigurd and Seifert, Roland and Dove, Stefan and Bernhardt, Günther and Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), pp. 232-240.

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

histamine H2 receptor agonist

Kraus, Anja and Ghorai, Prasanta and Birnkammer, Tobias and Schnell, David and Elz, Sigurd and Seifert, Roland and Dove, Stefan and Bernhardt, Günther and Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), pp. 232-240.

histamine H2 receptor agonists

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

Dove, Stefan and Buschauer, Armin (1999) Improved Alignment by Weighted Field Fit in CoMFA of Histamine H_2 Receptor Agonistic Imidazolylpropylguanidines. Quant. Struct.-Act. Relat. 18 (4), pp. 329-341.

Dove, Stefan and Buschauer, Armin (1998) Imidazolylpropylguanidines as histamine H_2 receptor agonists: 3D-QSAR of a large series. Pharm. Acta Helv. 73 (3), pp. 145-155.

Histamine H2 receptor antagonists

Wolf, Cornelia and Schulze, Frank R. and Buschauer, Armin and Schunack, Walter (1998) Combined histamine H_1/H_2 receptor antagonists: Part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures,. European Journal of Pharmaceutical Sciences 6 (3), pp. 187-196.

Histamine H2-receptor agonist

Xie, Sheng-Xue and Petrache, Georgiana and Schneider, Erich and Ye, Qi-Zhuang and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorganic & Medicinal Chemistry Letters 16 (15), pp. 3886-3890.

histamine H3 receptor

Igel, Patrick and Geyer, Roland and Straßer, Andrea and Dove, Stefan and Seifert, Roland and Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), pp. 6297-6313.

Igel, Patrick and Schnell, David and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), pp. 225-231.

histamine H4 receptor

Brunskole, Irena (2011) Molecular and cellular analysis of aminergic G protein-coupled receptors: histamine H2, H4 and β2-adrenergic receptors, a scientific paradigm. PhD, Universität Regensburg

Brunskole, Irena and Strasser, Andrea and Seifert, Roland and Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), pp. 301-317.

Igel, Patrick and Geyer, Roland and Straßer, Andrea and Dove, Stefan and Seifert, Roland and Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), pp. 6297-6313.

Igel, Patrick and Schnell, David and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), pp. 225-231.

Histamine H4-receptor

Reher, Till M. and Neumann, Detlef and Buschauer, Armin and Seifert, Roland (2012) Incomplete activation of human eosinophils via the histamine H(4)-receptor: Evidence for ligand-specific receptor conformations. Biochemical Pharmacology 84 (2), pp. 192-203.

Schnell, David and Brunskole, Irena and Ladova, Katerina and Schneider, Erich H. and Igel, Patrick and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470.

Histamine H₁ receptor

Xie, Sheng-Xue and Schalkhausser, Fabian and Ye, Qi-Zhuang and Seifert, Roland and Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), pp. 9-16.

Histamine H₂ receptor

Xie, Sheng-Xue and Schalkhausser, Fabian and Ye, Qi-Zhuang and Seifert, Roland and Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), pp. 9-16.

histamine receptors

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

Ghorai, Prasanta and Kraus, Anja and Keller, Max and Götte, Carsten and Igel, Patrick and Schneider, Erich and Schnell, David and Bernhardt, Günther and Dove, Stefan and Zabel, Manfred and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.

Histaminrezeptor

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

Histaminrezeptorsynergist

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

HLH motif

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

Hoechst 33342

Ochoa Puentes, Cristian and Höcherl, Peter and Kühnle, Matthias and Bauer, Stefanie and Kürger, Kira and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2). Bioorganic & Medicinal Chemistry Letters 21 (12), pp. 3654-3657.

Hormon-abhängiger Brustkrebs

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Hormone-dependent breast cancer

Zimmermann, Jochen and Angerer, Erwin von (2007) Estrogenic and antiestrogenic activities of 2,4-diphenylfuran-based ligands of estrogen receptors α and β. The Journal of Steroid Biochemistry and Molecular Biology 104 (3-5), pp. 259-268.

Hormone-dependent brest cancer

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Hospitalismus <Hygiene>

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

Huisgen reaction

Weiss, Stefan and Keller, Max and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), pp. 9858-9866.

Human

Bernhardt, Günther and Brunner, Henri and Gruber, Nick and Lottner, Christian and Pushpan, Simi K. and Tsuno, Takashi and Zabel, Manfred (2004) Carboplatin derivatives with superior antitumor activity compared to the parent compound. Inorganica Chimica Acta 357 (15), pp. 4452-4466.

Hyal-1

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Hyaluronan

Spickenreither, Martin and Braun, Stephan and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2006) Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorganic & Medicinal Chemistry Letters 16 (20), pp. 5313-5316.

hyaluronan analytics

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

Hyaluronan lyase inhibitors

Braun, Stephan and Botzki, Alexander and Salmen, Sunnhild and Textor, Christian and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2011) Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase. European Journal of Medicinal Chemistry 46 (9), pp. 4419-4429.

Hyaluronan lyases

Spickenreither, Martin and Braun, Stephan and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2006) Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorganic & Medicinal Chemistry Letters 16 (20), pp. 5313-5316.

hyaluronate lyase

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Salmen, Sunnhild and Hoechstetter, Julia and Käsbauer, Christian and Paper, Dieter H. and Bernhardt, Günther and Buschauer, Armin (2005) Sulphated Oligosaccharides as Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus agalactiae. Planta Med. 71, pp. 727-732.

Oettl, Martin and Hoechstetter, Julia and Asen, Iris and Bernhardt, Günther and Buschauer, Armin (2003) Comparative characterization of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae in pharmaceutical preparations. European Journal of Pharmaceutical Sciences 18 (3-4), pp. 267-277.

hyaluronic acid

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Salmen, Sunnhild and Hoechstetter, Julia and Käsbauer, Christian and Paper, Dieter H. and Bernhardt, Günther and Buschauer, Armin (2005) Sulphated Oligosaccharides as Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus agalactiae. Planta Med. 71, pp. 727-732.

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

hyaluronidase

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

Muckenschnabel, I. and Bernhardt, Günther and Spruß, Thilo and Buschauer, Armin (1998) Pharmacokinetics and tissue distribution of bovine testicular hyaluronidase and vinblastine in mice: an attempt to optimize the mode of adjuvant hyaluronidase administration in cancer chemotherapy. Cancer Letters 131 (1), pp. 71-84.

hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors)

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

Hyaluronidase inhibitors

Spickenreither, Martin and Braun, Stephan and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2006) Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorganic & Medicinal Chemistry Letters 16 (20), pp. 5313-5316.

Hyaluronidase inhibitors • LUDI • Property distribution • Structure-based design

Botzki, Alexander and Salmen, Sunnhild and Bernhardt, Günther and Buschauer, Armin and Dove, Stefan (2005) Structure-Based Design Of Bacterial Hyaluronan Lyase Inhibitors,. QSAR & Combinatorial Science 24 (4), pp. 458-469.

Hyaluronidasen

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

hyaluronidases

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

Hyaluronsäure

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

Hyaluronsäure-Analytik

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

Hydrolysis kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes) Substituent effects (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes vs. breast cancer cytotoxicity) Substitution reaction kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes with iodide) Antitumor agents (platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes as) platinum bisfluorophenylethylenediamine acetate deriv prepn cytotoxicity fluorophenylethylenediamine platinum acetate deriv prepn cytotoxicity cytotoxicity platinum bisfluorophenylethylenediamine acetate deriv substituent kinetics substitution platinum bisfluorophenylethylenediamine acetate deriv breast cancer cytotoxicity platinum bisfluorophenylethylenediamine acetate diastereoisomer platinum bisfluorophenylethylenediamine acetate prepn cytotoxicity

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1996) Breast cancer inhibiting diastereomeric diacetato[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) derivatives: synthesis and studies on the relationship between reactivity and antitumor activity. Inorganica chimica acta 250 (1-2), pp. 203-218.

hyperthermic limb perfusion cytostatic chemosensitivity

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

Id Proteine

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

Id proteins

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

Id3 Protein

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

Imidazol

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

imidazole

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

imidazolylpropylguanidine

Igel, Patrick and Schnell, David and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), pp. 225-231.

immunosuppression

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

Immunsuppression

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

Impromidine

Xie, Sheng-Xue and Schalkhausser, Fabian and Ye, Qi-Zhuang and Seifert, Roland and Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), pp. 9-16.

impromidine analogues

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

indole-3-butyric acid

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

indoles

Igel, Patrick and Dove, Stefan and Buschauer, Armin (2010) Histamine H4 receptor agonists. Bioorganic & Medicinal Chemistry Letters 20 (24), pp. 7191-7199.

inflammation

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

Inhibitor

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg

Inhibitorproteine

Colombo, Noemi (2007) Synthesis and conformational analysis of polypeptides related to the inhibitor of the DNA binding and cell differentiation Id2. PhD, Universität Regensburg

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

inhibitors

Salmen, Sunnhild and Hoechstetter, Julia and Käsbauer, Christian and Paper, Dieter H. and Bernhardt, Günther and Buschauer, Armin (2005) Sulphated Oligosaccharides as Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus agalactiae. Planta Med. 71, pp. 727-732.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

inhibitors [Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

inhibitors platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) platinum fluorophenylethylenediamine DMSO prepn breast antitumor agent

Gust, Ronald and Heinrich, Heike and Krauser, Rudolf and Schönenberger, Helmut (1999) [Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities. Inorganica chimica acta 285 (2), pp. 184-189.

inhibitors prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Substitution reaction kinetics (nucleophilic of platinum fluorophenylethylenediamine dicarboxylato complexes with iodide) Carboxylic acids Role: BAC (Biological activity or effector

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

innate immunsystem

Hähnel, Viola (2003) Die transkriptionelle Regulation der Toll-like Rezeptoren (TLR2, TLR3 und TLR4) in mononukleären Phagozyten. PhD, Universität Regensburg

Interleukin-11

Kießling, Stephan (2002) Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors alpha in humanen Kolonepithelzellen. PhD, Universität Regensburg

Kießling, Stephan (2002) Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors alpha in humanen Kolonepithelzellen. PhD, Universität Regensburg

Intracellular calcium concentration

Reher, Till M. and Neumann, Detlef and Buschauer, Armin and Seifert, Roland (2012) Incomplete activation of human eosinophils via the histamine H(4)-receptor: Evidence for ligand-specific receptor conformations. Biochemical Pharmacology 84 (2), pp. 192-203.

Ischemia

Weiss, Thomas S. and Bernhardt, Günther and Buschauer, Armin and Thasler, Wolfgang E. and Dolgner, Doris and Zirngibl, Hubert and Jauch, Karl-Walter (2002) Polyamine levels of human colorectal adenocarcinomas are correlate with tumor stage and grade,. International Journal of Colorectal Disease 17 (6), pp. 381-387.

Isolierung <Chemie>

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Isotopenmarkierung

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

JNJ7777120

Brunskole, Irena and Strasser, Andrea and Seifert, Roland and Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), pp. 301-317.

Schnell, David and Brunskole, Irena and Ladova, Katerina and Schneider, Erich H. and Igel, Patrick and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470.

K+-channel-inhibitors

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Kalium-Kanal-Inhibitoren

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Kaliumkanal

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Kapillarelektrophorese

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Kinesin

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Kinesin Eg5

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Kinesin inhibitors - Monastrol analogues - Human glioblastoma cells - Chemosensitivity - Confocal microscopy

Müller, Christine and Gross, Dietmar and Sarli, Vasiliki and Gartner, Michael and Giannis, Athanassios and Bernhardt, Günther and Buschauer, Armin (2007) Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells. Cancer Chemotherapy and Pharmacology 59 (2), pp. 157-164.

Kinetics

Bernhardt, Günther and Rudolph, Rainer and Jaenicke, Rainer (1981) Reassociation of lactic dehydrogenase from pig heart studied by cross-linking with glutaraldehyde. Zeitschrift fuer Naturforschung, C Journal of Biosciences 36C (9-10), pp. 772-777.

kinetics of)

Bernhardt, Günther and Rudolph, Rainer and Jaenicke, Rainer (1981) Reassociation of lactic dehydrogenase from pig heart studied by cross-linking with glutaraldehyde. Zeitschrift fuer Naturforschung, C Journal of Biosciences 36C (9-10), pp. 772-777.

Konformation

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

Konformationsanalyse

Colombo, Noemi (2007) Synthesis and conformational analysis of polypeptides related to the inhibitor of the DNA binding and cell differentiation Id2. PhD, Universität Regensburg

Konstitutive Aktivität

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Krebs <Medizin>

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Krebszelle

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

labeled ligand

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Lactam formation

Brennauer, Albert and Keller, Max and Freund, Matthias and Bernhardt, Günther and Buschauer, Armin (2007) Decomposition of 1-(w-aminoalkanoyl)guanidines under alkaline conditions. Tetrahedron Letters 48 (39), pp. 6996-6999.

lactate dehydrogenase subunit assembly

Bernhardt, Günther and Rudolph, Rainer and Jaenicke, Rainer (1981) Reassociation of lactic dehydrogenase from pig heart studied by cross-linking with glutaraldehyde. Zeitschrift fuer Naturforschung, C Journal of Biosciences 36C (9-10), pp. 772-777.

Leber

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Leberregeneration

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Leberzellkrebs

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Ligand <Biochemie>

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Limb perfusion • Rat • Online monitoring • Oxygen-microoptodes • Perfusion pressure

Gürtler, Ulrich and Fuchs, Peter and Stangelmayer, Achim and Bernhardt, Günther and Buschauer, Armin and Spruss, Thilo (2004) Construction and validation of a microprocessor controlled extracorporal circuit in rats for the optimization of isolated limb perfusion. Archiv der Pharmazie 33 (12), pp. 672-681.

Limited proteolysis

Oettl, Martin and Hoechstetter, Julia and Asen, Iris and Bernhardt, Günther and Buschauer, Armin (2003) Comparative characterization of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae in pharmaceutical preparations. European Journal of Pharmaceutical Sciences 18 (3-4), pp. 267-277.

Lipid efflux

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Lipidefflux

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Lipophilicity

Egger, Michael and Li, Xuqin and Müller, Christine and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2007) Tariquidar analogues: synthesis by Cu(I)-catalysed N/O–aryl coupling and inhibitory activity against the ABCB1 transporter. European Journal of Organic Chemistry 2007 (16), pp. 2643-2649.

liposomes

Posavec, Damir (2011) Adjustment of the decay kinetics of photogenerated endoperoxides embedded in various carrier materials aiming at medical applications. PhD, Universität Regensburg

liver

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

liver regeneration

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

LNCaP prostate carcinoma cells

Maucher, A. and Angerer, E. von (1993) Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours. Journal of cancer research and clinical oncology 119 (11), pp. 669-674.

Local therapy

Vogelhuber, Werner and Spruß, Thilo and Bernhardt, Günther and Buschauer, Armin and Göpferich, Achim (2002) Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts,. International Journal of Pharmaceutics 238 (1-2), pp. 111-121.

Low-density-Lipoproteine

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

lung cancer

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Lungentumore

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Lymphotoxin

Stopfer, Peter (2003) Biologische Wirkungen der Aktivierung des Lymphotoxin-beta-Rezeptors. PhD, Universität Regensburg

lymphotoxin-beta-receptor

Stopfer, Peter (2003) Biologische Wirkungen der Aktivierung des Lymphotoxin-beta-Rezeptors. PhD, Universität Regensburg

Lymphotoxin-beta-Rezeptor

Stopfer, Peter (2003) Biologische Wirkungen der Aktivierung des Lymphotoxin-beta-Rezeptors. PhD, Universität Regensburg

Lysosomal sorting

Parker, Steven L. and Parker, Michael S. and Buschauer, Armin and Balasubramaniam, Ambikaipakan (2003) Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides. European Journal of Pharmacology 474 (1), pp. 31-42.

Lysosome

Parker, S.L. and Parker, M. S. and Lundell, I. and Balasubramaniam, A. and Buschauer, Armin and Kane, J. K. and Yalcin, A. and Berglund, M. M. (2002) Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling. Regulatory Peptides 107 (1-3), pp. 49-62.

macrophage migration inhibitory factor

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

Magentumor

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Magnetische Kernresonanz

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

Malignant brain tumor

Vogelhuber, Werner and Spruß, Thilo and Bernhardt, Günther and Buschauer, Armin and Göpferich, Achim (2002) Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts,. International Journal of Pharmaceutics 238 (1-2), pp. 111-121.

Malignant melanoma

Muckenschnabel, I. and Bernhardt, Günther and Spruß, Thilo and Buschauer, Armin (1998) Pharmacokinetics and tissue distribution of bovine testicular hyaluronidase and vinblastine in mice: an attempt to optimize the mode of adjuvant hyaluronidase administration in cancer chemotherapy. Cancer Letters 131 (1), pp. 71-84.

Mammary gland (neoplasm

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

mast cell

Stopfer, Peter (2003) Biologische Wirkungen der Aktivierung des Lymphotoxin-beta-Rezeptors. PhD, Universität Regensburg

Mastzelle

Stopfer, Peter (2003) Biologische Wirkungen der Aktivierung des Lymphotoxin-beta-Rezeptors. PhD, Universität Regensburg

Matrix Metalloproteinase 2: AI

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Matrix Metalloproteinase 9: AI

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

MCF-7 breast cancer cells

Kühnle, Matthias and Egger, Michael and Müller, Christine and Mahringer, Anne and Bernhardt, Günther and Fricker, Gert and König, Burkhard and Buschauer, Armin (2009) Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. Journal of Medicinal Chemistry 52 (4), pp. 1190-1197.

Keller, Max and Pop, Nathalie and Hutzler, Christoph and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2008) Guanidine - acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. Journal of Medicinal Chemistry 51 (24), pp. 8168-8172.

MCP-4

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

MDR

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

medical applications

Posavec, Damir (2011) Adjustment of the decay kinetics of photogenerated endoperoxides embedded in various carrier materials aiming at medical applications. PhD, Universität Regensburg

medicinal chemistry

Birnkammer, Tobias (2011) Highly potent and selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships of mono- and bivalent ligands. PhD, Universität Regensburg

Weiss, Stefan and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Synthesis and characterization of DMAP-Modified NPY Y1 receptor antagonists as acyl-transfer catalysts. Collection of Czechoslovak chemical communications 76 (6), 763 -780.

Egger, Michael and Li, Xuqin and Müller, Christine and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2007) Tariquidar analogues: synthesis by Cu(I)-catalysed N/O–aryl coupling and inhibitory activity against the ABCB1 transporter. European Journal of Organic Chemistry 2007 (16), pp. 2643-2649.

metabolism

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Metalloendopeptidases: ME

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Metastases

Maucher, A. and Kager, M. and Angerer, E. von (1993) Evaluation of the antitumour activity of coumarin in prostate cancer models. Journal of cancer research and clinical oncology 119 (3), pp. 150-154.

MFM (Metabolic formation)

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Mitogen-activated protein kinase

Bischoff, Andrea and Püttmann, Kristina and Kötting, Annette and Moser, Christiane and Buschauer, Armin and Michel, Martin C. (2001) Limited signal transduction repertoire of human Y_5 neuropeptide Y receptors expressed in HEC-B cells. Peptides 22 (3), pp. 387-394.

Models

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

mol. structure)

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Molecular association (of lactate dehydrogenase subunits

Bernhardt, Günther and Rudolph, Rainer and Jaenicke, Rainer (1981) Reassociation of lactic dehydrogenase from pig heart studied by cross-linking with glutaraldehyde. Zeitschrift fuer Naturforschung, C Journal of Biosciences 36C (9-10), pp. 772-777.

molecular design

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg

molecular dynamics

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Molecular modeling * Receptor binding studies

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

molecular modelling

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

Molecular recognition

Weiss, Stefan and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Synthesis and characterization of DMAP-Modified NPY Y1 receptor antagonists as acyl-transfer catalysts. Collection of Czechoslovak chemical communications 76 (6), 763 -780.

Molecular structure ([rac-1

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Molecular structure-biological activity relationship (neoplasm-inhibiting

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Molekulardesign

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg

Molekulardynamik

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Monozyten-Makrophagen-System

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

multichromophore systems

Posavec, Damir (2011) Adjustment of the decay kinetics of photogenerated endoperoxides embedded in various carrier materials aiming at medical applications. PhD, Universität Regensburg

Multidrug-Resistenz

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Mustererkennung

Hähnel, Viola (2003) Die transkriptionelle Regulation der Toll-like Rezeptoren (TLR2, TLR3 und TLR4) in mononukleären Phagozyten. PhD, Universität Regensburg

MXT mouse mammary tumour

Maucher, A. and Angerer, E. von (1993) Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours. Journal of cancer research and clinical oncology 119 (11), pp. 669-674.

Myelose

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Nachweis

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

nanoparticles

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Nanopartikel

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

neoplasm (cisplatin-resistant

Bernhardt, Günther and Brunner, Henri and Gruber, Nick and Lottner, Christian and Pushpan, Simi K. and Tsuno, Takashi and Zabel, Manfred (2004) Carboplatin derivatives with superior antitumor activity compared to the parent compound. Inorganica Chimica Acta 357 (15), pp. 4452-4466.

neoplasm inhibiting activity in relation to) acetoxyphenylindene ethylmethylacetoxy prepn tumor inhibitor indene acetoxyphenyl anticancer

Schneider, Martin R. and von Angerer, Erwin and Schönenberger, Helmut (1982) 5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound. European journal of medicinal chemistry 17 (3), pp. 245-248.

Neoplasm inhibitors (acetoxy(acetoxyphenyl)ethylmethylindene) Receptors Role: RCT (Reactant)

Schneider, Martin R. and von Angerer, Erwin and Schönenberger, Helmut (1982) 5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound. European journal of medicinal chemistry 17 (3), pp. 245-248.

Neoplasm inhibitors (discrepancy between cytotoxicity and platinum accumulation and DNA platination in MCF-7 breast cancer cells treated with diaqua(diphenylethylenediamine)

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Neoplasm inhibitors (mammary gland

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Neoplasm inhibitors (melanoma

Spruss, Thilo and Bernhardt, Günther (1996) Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy. In: Arnold, Wolfgang, (ed.) Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology, 51. UNSPECIFIED, pp. 145-150.

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

Neoplasm inhibitors (platinated DNA after treatment of cancer cells with new platinum complexes)

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

Neoplasm inhibitors (platinum ammine chloro complexes with aminoethoxyestrone or -estradiol as)

Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.

Neoplasm inhibitors (platinum complexes with bis(fluorophenyl)ethylenediamines)

Mueller, Richard and Gust, Ronald and Jennerwein, Margaretha and Reile, Herta and Laske, Reiner and Krischke, Walter and Bernhardt, Günther and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1989) Tumor inhibiting [1,2-bis(fluorophenylethylenediamine]platinum(II) complexes. Part I. Synthesis. European Journal of Medicinal Chemistry 24 (4), pp. 341-348.

Neoplasm inhibitors Role: BAC (Biological activity or effector

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

neoplasms (hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors)

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

neoplasms (inhibitors

Pillwein, Konrad and Fuiko, R. and Slavc, I. and Czech, T. and Hawliczek, G. and Bernhardt, Günther and Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.

Neuropeptid Y

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

Neuropeptid Y Y1 Rezeptor

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Neuropeptid Y Y1-Rezeptorantagonist

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

neuropeptide Y

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

Pluym, Nikola and Brennauer, Albert and Keller, Max and Ziemek, Ralf and Pop, Nathalie and Bernhardt, Günther and Buschauer, Armin (2011) Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists. ChemMedChem 6 (9), pp. 1727-1738.

Keller, Max and Bernhardt, Günther and Buschauer, Armin (2011) [3H]UR-MK136 - a highly potent and selective radioligand for neuropeptide Y Y1 receptors. ChemMedChem 6 (9), pp. 1566-1571.

Weiss, Stefan and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Synthesis and characterization of DMAP-Modified NPY Y1 receptor antagonists as acyl-transfer catalysts. Collection of Czechoslovak chemical communications 76 (6), 763 -780.

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Keller, Max and Teng, Shangjun and Bernhardt, Günther and Buschauer, Armin (2009) Bivalent argininamide-type neuropeptide Y Y1 antagonists do not support the hypothesis of receptor dimerisation. ChemMedChem 4 (10), pp. 1733-1745.

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Keller, Max and Pop, Nathalie and Hutzler, Christoph and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2008) Guanidine - acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. Journal of Medicinal Chemistry 51 (24), pp. 8168-8172.

Weiss, Stefan and Keller, Max and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), pp. 9858-9866.

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

Ziemek, Ralf and Brennauer, Albert and Schneider, Erich and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2006) Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y(2) receptor ligands. European Journal of Pharmacology 551 (1-3), pp. 10-8.

neuropeptide Y Y1 receptor

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Neuropeptide Y Y1 Receptor Antagonist

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

neuropeptide Y Y2 receptor

Pop, Nathalie and Igel, Patrick and Brennauer, Albert and Cabrele, Chiara and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2011) Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells. Journal of Receptors and Signal Transduction 31 (4), pp. 271-285.

neuropeptide Y Y4 receptor

Pop, Nathalie and Igel, Patrick and Brennauer, Albert and Cabrele, Chiara and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2011) Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells. Journal of Receptors and Signal Transduction 31 (4), pp. 271-285.

neutrophil granulocytes

Brunskole, Irena (2011) Molecular and cellular analysis of aminergic G protein-coupled receptors: histamine H2, H4 and β2-adrenergic receptors, a scientific paradigm. PhD, Universität Regensburg

NG-Acylguanidine

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

NG-Acylguanidines

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

Nicht-kleinzelliges Bronchialkarzinom

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

NMR-Spektroskopie

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

Noble tumour

Maucher, A. and Kager, M. and Angerer, E. von (1993) Evaluation of the antitumour activity of coumarin in prostate cancer models. Journal of cancer research and clinical oncology 119 (3), pp. 150-154.

Non-steroidal estrogen

Zimmermann, Jochen and Angerer, Erwin von (2007) Estrogenic and antiestrogenic activities of 2,4-diphenylfuran-based ligands of estrogen receptors α and β. The Journal of Steroid Biochemistry and Molecular Biology 104 (3-5), pp. 259-268.

Nonpeptide NPY Y4 receptor antagonist

Ziemek, Ralf and Schneider, Erich and Kraus, Anja and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2007) Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence. Journal of Receptors and Signal Transduction 27 (4), pp. 217-233.

nonpreparative)

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Nonsteroidal antiandrogen

Maucher, A. and Angerer, E. von (1993) Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours. Journal of cancer research and clinical oncology 119 (11), pp. 669-674.

nosocomial infection

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

NPY

Pluym, Nikola (2011) Application of the guanidine–acylguanidine bioisosteric approach to NPY Y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools. PhD, Universität Regensburg

Pluym, Nikola and Brennauer, Albert and Keller, Max and Ziemek, Ralf and Pop, Nathalie and Bernhardt, Günther and Buschauer, Armin (2011) Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists. ChemMedChem 6 (9), pp. 1727-1738.

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Weiss, Stefan and Keller, Max and Bernhardt, G. and Buschauer, Armin and König, Burkhard (2010) N(G)-Acyl-argininamides as NPY Y (1) receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity. Bioorganic & Medicinal Chemistry (18), pp. 6292-6304.

Keller, Max and Pop, Nathalie and Hutzler, Christoph and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2008) Guanidine - acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. Journal of Medicinal Chemistry 51 (24), pp. 8168-8172.

Weiss, Stefan and Keller, Max and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), pp. 9858-9866.

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

NPY receptors

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

NPY Rezeptoren

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

NPY Y1 receptor

Keller, Max and Bernhardt, Günther and Buschauer, Armin (2011) [3H]UR-MK136 - a highly potent and selective radioligand for neuropeptide Y Y1 receptors. ChemMedChem 6 (9), pp. 1566-1571.

Keller, Max and Erdmann, Daniela and Teng, Shangjun and Pop, Nathalie and Pluym, Nikola and Bernhardt, Günther and Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), pp. 2859-2878.

NPY Y4 receptor

Ziemek, Ralf and Schneider, Erich and Kraus, Anja and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2007) Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence. Journal of Receptors and Signal Transduction 27 (4), pp. 217-233.

o-phthaldialdehyde

Schuster, Andreas and Götte, Carsten and Bernhardt, Günther and Buschauer, Armin (2001) Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,. Chirality 13 (6), pp. 285-293.

of dichlorobis(cycloalkylamine)platinum(II) complexes)

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Opsonine

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

opsonins

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

Opsonisierung

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

optical imaging

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg

Optisches Imaging

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg

Organische Synthese

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Ornithine decarboxylase

Weiss, Thomas S. and Bernhardt, Günther and Buschauer, Armin and Thasler, Wolfgang E. and Dolgner, Doris and Zirngibl, Hubert and Jauch, Karl-Walter (2002) Polyamine levels of human colorectal adenocarcinomas are correlate with tumor stage and grade,. International Journal of Colorectal Disease 17 (6), pp. 381-387.

OUP-16

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Ovary

Bernhardt, Günther and Brunner, Henri and Gruber, Nick and Lottner, Christian and Pushpan, Simi K. and Tsuno, Takashi and Zabel, Manfred (2004) Carboplatin derivatives with superior antitumor activity compared to the parent compound. Inorganica Chimica Acta 357 (15), pp. 4452-4466.

Ox-LDL

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

oximes

Igel, Patrick and Dove, Stefan and Buschauer, Armin (2010) Histamine H4 receptor agonists. Bioorganic & Medicinal Chemistry Letters 20 (24), pp. 7191-7199.

Oxo-arpromidine

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

P-glycoprotein

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

Kühnle, Matthias and Egger, Michael and Müller, Christine and Mahringer, Anne and Bernhardt, Günther and Fricker, Gert and König, Burkhard and Buschauer, Armin (2009) Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. Journal of Medicinal Chemistry 52 (4), pp. 1190-1197.

paclitaxel

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

Vogelhuber, Werner and Spruß, Thilo and Bernhardt, Günther and Buschauer, Armin and Göpferich, Achim (2002) Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts,. International Journal of Pharmaceutics 238 (1-2), pp. 111-121.

PDGF receptor

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

PDGF Rezeptor

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Peptidanaloga

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

Peptide

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

peptide synthesis and characterization

Colombo, Noemi (2007) Synthesis and conformational analysis of polypeptides related to the inhibitor of the DNA binding and cell differentiation Id2. PhD, Universität Regensburg

Peptidomimetikum

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Peptidsynthese

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

PGP

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

pH profiles

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

PH-20

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

pH-Profile

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

Phagozyt

Hähnel, Viola (2003) Die transkriptionelle Regulation der Toll-like Rezeptoren (TLR2, TLR3 und TLR4) in mononukleären Phagozyten. PhD, Universität Regensburg

Phagozytose

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg

Pharmaceutical Germany

Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2008) Frontiers in medicinal chemistry in Regensburg. ChemMedChem 3 (8), pp. 1181-1184.

pharmaceutical carriers

Posavec, Damir (2011) Adjustment of the decay kinetics of photogenerated endoperoxides embedded in various carrier materials aiming at medical applications. PhD, Universität Regensburg

Pharmaceutical dosage forms (hydrosols

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

pharmacological in vitro assays

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

pharmacological tools

Pluym, Nikola (2011) Application of the guanidine–acylguanidine bioisosteric approach to NPY Y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools. PhD, Universität Regensburg

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Pharmacologie

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

pharmacology

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

pharmakologische Assays

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

pharmakologische In-vitro-Assays

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

Pharmakologischer Antagonist

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Pheniramine

Wolf, Cornelia and Schulze, Frank R. and Buschauer, Armin and Schunack, Walter (1998) Combined histamine H_1/H_2 receptor antagonists: Part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures,. European Journal of Pharmaceutical Sciences 6 (3), pp. 187-196.

Phenylpyridylpropylamines

Schuster, Andreas and Bernhardt, Günther and Eibler, Ernst and Buschauer, Armin and Hesselink, Willy (1998) Chiral separation of 3-phenyl-3-(2-pyridyl)propylamines, and analogous guanidines and guanidine-N-carboxylic acid esters with HPLC and CZE. Journal of Chromatography A 793 (1), pp. 77-90.

Phospholipase C

Bischoff, Andrea and Püttmann, Kristina and Kötting, Annette and Moser, Christiane and Buschauer, Armin and Michel, Martin C. (2001) Limited signal transduction repertoire of human Y_5 neuropeptide Y receptors expressed in HEC-B cells. Peptides 22 (3), pp. 387-394.

Phosphorylation

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

Photodynamic therapy

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

Photosensitizers

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

Phototoxicity (prepn. of water-sol. platinum porphyrin amine complexes with high tumor selectivity for use in photodynamic therapy)

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

Piperidinomethylalkylamine

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Platelet-derived Growth Factor

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Platelet-derived growth factor receptor - Human glioblastoma cells - Imatinib

Gross, Dietmar and Bernhardt, Günther and Buschauer, Armin (2006) Platelet-derived growth factor receptor independent proliferation of human glioblastoma cells: selective tyrosine kinase inhibitors lack antiproliferative activity. Journal of Cancer Research and Clinical Oncology 132 (9), pp. 589-599.

platinum prepn.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

platinum complex antitumor platinated DNA

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

platinum complex prepn stability neoplasm inhibition

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

platinum complexes prepn. and stereoselectivity in antitumor activity of [1

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

platinum cycloalkylamine chloro antitumor prepn structure

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

platinum porphyrin amine prepn antitumor photodynamic therapy

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

platinum(II) sulfates and cisplatin in MCF-7 human breast cancer cells)

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Polyamines

Weiss, Thomas S. and Bernhardt, Günther and Buschauer, Armin and Thasler, Wolfgang E. and Dolgner, Doris and Zirngibl, Hubert and Jauch, Karl-Walter (2002) Polyamine levels of human colorectal adenocarcinomas are correlate with tumor stage and grade,. International Journal of Colorectal Disease 17 (6), pp. 381-387.

Polyanhydride

Vogelhuber, Werner and Spruß, Thilo and Bernhardt, Günther and Buschauer, Armin and Göpferich, Achim (2002) Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts,. International Journal of Pharmaceutics 238 (1-2), pp. 111-121.

polymer nanoparticles

Posavec, Damir (2011) Adjustment of the decay kinetics of photogenerated endoperoxides embedded in various carrier materials aiming at medical applications. PhD, Universität Regensburg

Porphyrins

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

Positronen-Emissions-Tomographie

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

PREP (Preparation)

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

PREP (Preparation) (carboxylic acid

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

PREP (Preparation) (diamines

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

PREP (Preparation) (mammary gland

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

PREP (Preparation) (neoplasm

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

PREP (Preparation) (transition metal complexes

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

prepn.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

prepn. of

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

prepn. of fluorophenyl- and difluorophenyl(p platinum fluorophenylethylenediamine deriv diastereomer prepn antitumor antitumor breast platinum fluorophenylethylenediamine deriv diastereomer

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

prepn. of fluorophenyl- and difluorophenyl(ph Mammary gland Role: BAC (Biological activity or effector

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

PROC (Process) ([Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

PROC (Process) (discrepancy between cytotoxicity and platinum accumulation and DNA platination in MCF-7 breast cancer cells treated with diaqua(diphenylethylenediamine) platinum(II) sulfates and cisplatin in MCF-7 human breast cancer cells) platinum compd cytotoxicity DNA platination tumor diaquadiphenylethylenediamine platinum cytotoxicity DNA platination tumor

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

PROC (Process) (platinated DNA after treatment of cancer cells with new platinum complexes)

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

Programmable release

Vogelhuber, W. and Rutunno, P. and Magni, E. and Gazzaniga, A. and Spruss, Thilo and Bernhardt, Günther and Buschauer, Armin and Goepferich, Achim (2001) Programmable biodegradable implants. Journal of Controlled Release 73 (1), pp. 75-88.

Promotor

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg

Prostate carcinoma

Maucher, A. and Kager, M. and Angerer, E. von (1993) Evaluation of the antitumour activity of coumarin in prostate cancer models. Journal of cancer research and clinical oncology 119 (3), pp. 150-154.

Protein kinase C

Bischoff, Andrea and Püttmann, Kristina and Kötting, Annette and Moser, Christiane and Buschauer, Armin and Michel, Martin C. (2001) Limited signal transduction repertoire of human Y_5 neuropeptide Y receptors expressed in HEC-B cells. Peptides 22 (3), pp. 387-394.

protein purification

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Protein-Protein Interaktion

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg

Proteine

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Proteinfaltung

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Proteinreinigung

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

PRP (Properties)

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Pulsatile release

Vogelhuber, W. and Rutunno, P. and Magni, E. and Gazzaniga, A. and Spruss, Thilo and Bernhardt, Günther and Buschauer, Armin and Goepferich, Achim (2001) Programmable biodegradable implants. Journal of Controlled Release 73 (1), pp. 75-88.

Punktmutation

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Pyranderivate

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

Pyrodictium occultum (high temp. and pressure effect on amino acids of

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

qsar

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

Quadratsäureamid

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

RACT (Reactant or reagent) (degrdn. and hydrolysis of

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

RACT (Reactant or reagent) (for estrogens

Schneider, Martin R. and von Angerer, Erwin and Schönenberger, Helmut (1982) 5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound. European journal of medicinal chemistry 17 (3), pp. 245-248.

radioactivity

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Radioaktivität

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Mosandl, Johannes (2009) Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells. PhD, Universität Regensburg

radiochemistry

Keller, Max and Bernhardt, Günther and Buschauer, Armin (2011) [3H]UR-MK136 - a highly potent and selective radioligand for neuropeptide Y Y1 receptors. ChemMedChem 6 (9), pp. 1566-1571.

radiolabeled H3 receptor ligand

Igel, Patrick and Schnell, David and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), pp. 225-231.

radiolabeled H4 receptor ligand

Igel, Patrick and Schnell, David and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), pp. 225-231.

radiolabeled Y1 receptor antagonist

Keller, Max and Pop, Nathalie and Hutzler, Christoph and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2008) Guanidine - acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. Journal of Medicinal Chemistry 51 (24), pp. 8168-8172.

radioligand

Pluym, Nikola (2011) Application of the guanidine–acylguanidine bioisosteric approach to NPY Y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools. PhD, Universität Regensburg

Keller, Max and Bernhardt, Günther and Buschauer, Armin (2011) [3H]UR-MK136 - a highly potent and selective radioligand for neuropeptide Y Y1 receptors. ChemMedChem 6 (9), pp. 1566-1571.

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

radioligand kinetics

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

Rafts

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Rats

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

reaction (of lactate dehydrogenase subunit assembly)

Bernhardt, Günther and Rudolph, Rainer and Jaenicke, Rainer (1981) Reassociation of lactic dehydrogenase from pig heart studied by cross-linking with glutaraldehyde. Zeitschrift fuer Naturforschung, C Journal of Biosciences 36C (9-10), pp. 772-777.

receptor

Keller, Max and Teng, Shangjun and Bernhardt, Günther and Buschauer, Armin (2009) Bivalent argininamide-type neuropeptide Y Y1 antagonists do not support the hypothesis of receptor dimerisation. ChemMedChem 4 (10), pp. 1733-1745.

Receptor affinity

Parker, Steven L. and Parker, Michael S. and Buschauer, Armin and Balasubramaniam, Ambikaipakan (2003) Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides. European Journal of Pharmacology 474 (1), pp. 31-42.

Receptor conservation

Parker, Steven L. and Parker, Michael S. and Buschauer, Armin and Balasubramaniam, Ambikaipakan (2003) Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides. European Journal of Pharmacology 474 (1), pp. 31-42.

receptor internalization

Lopuch, Miroslaw (2011) Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods. PhD, Universität Regensburg

receptor selectivity

Birnkammer, Tobias and Spickenreither, Anja and Brunskole, Irena and Lopuch, Miroslaw and Kagermeier, Nicole and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2012) The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. Journal of Medicinal Chemistry 55 (3), pp. 1147-1160.

receptor selectivity GTPase assay aminothiazoles

Kraus, Anja and Ghorai, Prasanta and Birnkammer, Tobias and Schnell, David and Elz, Sigurd and Seifert, Roland and Dove, Stefan and Bernhardt, Günther and Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), pp. 232-240.

receptor species orthologs

Schnell, David and Brunskole, Irena and Ladova, Katerina and Schneider, Erich H. and Igel, Patrick and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470.

receptors

Schneider, Erich and Mayer, Matthias and Ziemek, Ralf and Li, Liantao and Hutzler, Christoph and Bernhardt, Günther and Buschauer, Armin (2006) A Simple and Powerful Flow Cytometric Method for the Simultaneous Determination of Multiple Parameters at G-Protein-coupled Receptor Subtypes. ChemBioChem 7 (9), pp. 1400-1409.

recombinant protein

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Regeneration

Dayoub, Rania (2010) Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions. PhD, Universität Regensburg

Rekombinantes Protein

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

Rezeptor

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Gross, Dietmar (2006) New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy. PhD, Universität Regensburg

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

Kießling, Stephan (2002) Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors alpha in humanen Kolonepithelzellen. PhD, Universität Regensburg

RGS protein

Pop, Nathalie and Igel, Patrick and Brennauer, Albert and Cabrele, Chiara and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2011) Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells. Journal of Receptors and Signal Transduction 31 (4), pp. 271-285.

rheumatoid arthritis

Wieser, Carsten (2004) Herpesvirus saimiri basierte Vektoren für die somatische Gentherapie der Rheumatoiden Arthritis. PhD, Universität Regensburg

rheumatoide Arthritis

Wieser, Carsten (2004) Herpesvirus saimiri basierte Vektoren für die somatische Gentherapie der Rheumatoiden Arthritis. PhD, Universität Regensburg

Rigidisierung

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

RNAi

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

RNS

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Role: PAC (Pharmacological activity)

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

Route of application

Muckenschnabel, I. and Bernhardt, Günther and Spruß, Thilo and Buschauer, Armin (1998) Pharmacokinetics and tissue distribution of bovine testicular hyaluronidase and vinblastine in mice: an attempt to optimize the mode of adjuvant hyaluronidase administration in cancer chemotherapy. Cancer Letters 131 (1), pp. 71-84.

SAR

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

Schaumzelle

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Schaumzellen

Schulz, Berta (2006) Untersuchungen zur Opsonin-Aktivität von CRP, SAP, A-beta42 und SAA und deren Rolle bei der Schaumzellbildung. PhD, Universität Regensburg

SDS–PAGE

Oettl, Martin and Hoechstetter, Julia and Asen, Iris and Bernhardt, Günther and Buschauer, Armin (2003) Comparative characterization of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae in pharmaceutical preparations. European Journal of Pharmaceutical Sciences 18 (3-4), pp. 267-277.

Selective agonist endocytosis

Parker, Steven L. and Parker, Michael S. and Buschauer, Armin and Balasubramaniam, Ambikaipakan (2003) Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides. European Journal of Pharmacology 474 (1), pp. 31-42.

Sepsis

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

Sf9 cells

Ghorai, Prasanta and Kraus, Anja and Birnkammer, Tobias and Geyer, Roland and Bernhardt, Günther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2010) Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.

Sf9 insect cells

Brunskole, Irena (2011) Molecular and cellular analysis of aminergic G protein-coupled receptors: histamine H2, H4 and β2-adrenergic receptors, a scientific paradigm. PhD, Universität Regensburg

Brunskole, Irena and Strasser, Andrea and Seifert, Roland and Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), pp. 301-317.

Pop, Nathalie and Igel, Patrick and Brennauer, Albert and Cabrele, Chiara and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2011) Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells. Journal of Receptors and Signal Transduction 31 (4), pp. 271-285.

Schnell, David and Brunskole, Irena and Ladova, Katerina and Schneider, Erich H. and Igel, Patrick and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470.

Sf9-Insektenzellen

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

singlet oxygen

Posavec, Damir (2011) Adjustment of the decay kinetics of photogenerated endoperoxides embedded in various carrier materials aiming at medical applications. PhD, Universität Regensburg

site-directed mutagenesis

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

SK-N-MC cells

Keller, Max and Pop, Nathalie and Hutzler, Christoph and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2008) Guanidine - acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. Journal of Medicinal Chemistry 51 (24), pp. 8168-8172.

Solid Phase Synthesis

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg

solid-phase peptide synthesis

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

species-selectivity

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Spezies-Selektivität

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Sphingolipide

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

sphingolipids

Schifferer, Rainer (2006) Charakterisierung des zellulären Lipideffluxes von primären, humanen Fibroblasten und Monozyten/Makrophagen. PhD, Universität Regensburg

Sphingolipidstoffwechsel

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

SPN (Synthetic preparation)

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

SPPS

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

spreading factor

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

squaramide

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

stability

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

steady-state GTPase assay

Brunskole, Irena and Strasser, Andrea and Seifert, Roland and Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), pp. 301-317.

Pop, Nathalie and Igel, Patrick and Brennauer, Albert and Cabrele, Chiara and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2011) Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells. Journal of Receptors and Signal Transduction 31 (4), pp. 271-285.

Streptococcus agalactiae

Braun, Stephan and Botzki, Alexander and Salmen, Sunnhild and Textor, Christian and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2011) Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase. European Journal of Medicinal Chemistry 46 (9), pp. 4419-4429.

Oettl, Martin and Hoechstetter, Julia and Asen, Iris and Bernhardt, Günther and Buschauer, Armin (2003) Comparative characterization of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae in pharmaceutical preparations. European Journal of Pharmaceutical Sciences 18 (3-4), pp. 267-277.

structure in relation to)

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

structure-activity relationship

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg

Structure-activity relationship (antitumor prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Antitumor agents Conformation Human Mammary gland (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Estrogen receptors Role: BSU (Biological study

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (2005) [N-Ethyl- and [N,N'-Diethyl-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): Structure and Cytotoxic/Estrogenic Activity in Breast Cancer Cells. Journal of Medicinal Chemistry 48 (23), pp. 7132-7144.

Structure-activity relationship (carboplatin derivs. with superior antitumor activity compared to the parent compd.)

Bernhardt, Günther and Brunner, Henri and Gruber, Nick and Lottner, Christian and Pushpan, Simi K. and Tsuno, Takashi and Zabel, Manfred (2004) Carboplatin derivatives with superior antitumor activity compared to the parent compound. Inorganica Chimica Acta 357 (15), pp. 4452-4466.

Structure-activity relationships

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

Kraus, Anja and Ghorai, Prasanta and Birnkammer, Tobias and Schnell, David and Elz, Sigurd and Seifert, Roland and Dove, Stefan and Bernhardt, Günther and Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), pp. 232-240.

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

Structure-based design

Braun, Stephan and Botzki, Alexander and Salmen, Sunnhild and Textor, Christian and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2011) Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase. European Journal of Medicinal Chemistry 46 (9), pp. 4419-4429.

Struktur-Aktivitäts-Beziehung

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Ghorai, Prasanta (2006) Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity. PhD, Universität Regensburg

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg

Struktur-Wirkungs-Beziehungen

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

subunit assembly of)

Bernhardt, Günther and Rudolph, Rainer and Jaenicke, Rainer (1981) Reassociation of lactic dehydrogenase from pig heart studied by cross-linking with glutaraldehyde. Zeitschrift fuer Naturforschung, C Journal of Biosciences 36C (9-10), pp. 772-777.

sulphated oligosaccharide

Salmen, Sunnhild and Hoechstetter, Julia and Käsbauer, Christian and Paper, Dieter H. and Bernhardt, Günther and Buschauer, Armin (2005) Sulphated Oligosaccharides as Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus agalactiae. Planta Med. 71, pp. 727-732.

Synhtesis

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg

Syntaxin 13

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg

synthesis

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

Targeted drug delivery

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Tariquidar

Ochoa Puentes, Cristian and Höcherl, Peter and Kühnle, Matthias and Bauer, Stefanie and Kürger, Kira and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2). Bioorganic & Medicinal Chemistry Letters 21 (12), pp. 3654-3657.

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies. PhD, Universität Regensburg

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Taxol

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Test

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

thermophilic microorganism in relation to)

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

THU (Therapeutic use)

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

TmHU

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

TNM

Weiss, Thomas S. and Bernhardt, Günther and Buschauer, Armin and Thasler, Wolfgang E. and Dolgner, Doris and Zirngibl, Hubert and Jauch, Karl-Walter (2002) Polyamine levels of human colorectal adenocarcinomas are correlate with tumor stage and grade,. International Journal of Colorectal Disease 17 (6), pp. 381-387.

toll-like receptor

Hähnel, Viola (2003) Die transkriptionelle Regulation der Toll-like Rezeptoren (TLR2, TLR3 und TLR4) in mononukleären Phagozyten. PhD, Universität Regensburg

Toll-like Rezeptoren

Hähnel, Viola (2003) Die transkriptionelle Regulation der Toll-like Rezeptoren (TLR2, TLR3 und TLR4) in mononukleären Phagozyten. PhD, Universität Regensburg

transcriptional regulation

Hähnel, Viola (2003) Die transkriptionelle Regulation der Toll-like Rezeptoren (TLR2, TLR3 und TLR4) in mononukleären Phagozyten. PhD, Universität Regensburg

Transfektion

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg

Transferrin

Parker, S.L. and Parker, M. S. and Lundell, I. and Balasubramaniam, A. and Buschauer, Armin and Kane, J. K. and Yalcin, A. and Berglund, M. M. (2002) Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling. Regulatory Peptides 107 (1-3), pp. 49-62.

Transferrinrezeptor

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg

Transition metal complexes Role: BAC (Biological activity or effector

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

tumor

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Tumor Necrosis Factor-alpha: ME

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

Tumor-Nekrose-Faktor

Pollak, Nils (2005) Die Rolle von MIF (macrophage migration inhibitory factor) in der Sepsis-induzierten Immunparalyse. PhD, Universität Regensburg

Tumorantigen

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Tumorimmunologie

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

Tumorzelle

Hantschel, Markus (2005) Durchflusszytometrische Analysen zur Expression des Hitzeschockproteins Hsp70 auf der Zelloberfläche von kolorektalen Primärtumoren und hepatischen Metastasen, Magenkarzinomen, Bronchialkarzinomen, Kopf-Hals-Tumoren und akuten myeloischen Leukämien. PhD, Universität Regensburg

ulcerative colitis

Stopfer, Peter (2003) Biologische Wirkungen der Aktivierung des Lymphotoxin-beta-Rezeptors. PhD, Universität Regensburg

unclassified)

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (2005) [N-Ethyl- and [N,N'-Diethyl-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): Structure and Cytotoxic/Estrogenic Activity in Breast Cancer Cells. Journal of Medicinal Chemistry 48 (23), pp. 7132-7144.

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

UR-PI376

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Geyer, Roland and Buschauer, Armin (2011) Synthesis and histamine H3 and H4 receptor activity of conformationally restricted cyanoguanidines related to UR-PI376. Archiv der Pharmazie 344 (12), pp. 775-785.

Igel, Patrick and Geyer, Roland and Straßer, Andrea and Dove, Stefan and Seifert, Roland and Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), pp. 6297-6313.

UR-PI97

Igel, Patrick and Geyer, Roland and Straßer, Andrea and Dove, Stefan and Seifert, Roland and Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), pp. 6297-6313.

UR-RG98

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

USES (Uses) (platinum complexes prepn. of water-sol. platinum porphyrin amine complexes with high tumor selectivity for use in photodynamic therapy)

Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri and Lottner, Christian (2003) Preparation of novel, water-soluble porphyrin platinum amine compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases.

UV spectroscopy

Brennauer, Albert and Keller, Max and Freund, Matthias and Bernhardt, Günther and Buschauer, Armin (2007) Decomposition of 1-(w-aminoalkanoyl)guanidines under alkaline conditions. Tetrahedron Letters 48 (39), pp. 6996-6999.

Vaccination

Vogelhuber, W. and Rutunno, P. and Magni, E. and Gazzaniga, A. and Spruss, Thilo and Bernhardt, Günther and Buschauer, Armin and Goepferich, Achim (2001) Programmable biodegradable implants. Journal of Controlled Release 73 (1), pp. 75-88.

Vektor <Genetik>

Wieser, Carsten (2004) Herpesvirus saimiri basierte Vektoren für die somatische Gentherapie der Rheumatoiden Arthritis. PhD, Universität Regensburg

viability in relation to)

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

Luedemann, Hans-Dietrich and Bernhardt, Günther and Jaenicke, Rainer and Koenig, Helmut and Stetter, Karl Otto (1984) Biomolecules are unstable under "black smoker" conditions. Naturwissenschaften 71 (11), pp. 583-586.

Vinblastine

Muckenschnabel, I. and Bernhardt, Günther and Spruß, Thilo and Buschauer, Armin (1998) Pharmacokinetics and tissue distribution of bovine testicular hyaluronidase and vinblastine in mice: an attempt to optimize the mode of adjuvant hyaluronidase administration in cancer chemotherapy. Cancer Letters 131 (1), pp. 71-84.

vinblastine hyaluronidase interaction melanoma inhibition

Spruss, Thilo and Bernhardt, Günther (1996) Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy. In: Arnold, Wolfgang, (ed.) Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology, 51. UNSPECIFIED, pp. 145-150.

viral vector

Wieser, Carsten (2004) Herpesvirus saimiri basierte Vektoren für die somatische Gentherapie der Rheumatoiden Arthritis. PhD, Universität Regensburg

virtual screening

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg

Vitamin C derivatives

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg

Vitamin C-Derivate

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg

Wang resin

Ochoa Puentes, Cristian and Höcherl, Peter and Kühnle, Matthias and Bauer, Stefanie and Kürger, Kira and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2). Bioorganic & Medicinal Chemistry Letters 21 (12), pp. 3654-3657.

water soly.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

weighted field fit

Dove, Stefan and Buschauer, Armin (1999) Improved Alignment by Weighted Field Fit in CoMFA of Histamine H_2 Receptor Agonistic Imidazolylpropylguanidines. Quant. Struct.-Act. Relat. 18 (4), pp. 329-341.

Wirkstoff

Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg

Wirkstoff-Rezeptor-Bindung

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

Preuß, Hendrik (2007) Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis. PhD, Universität Regensburg

Wistar

Dittmar, Michael and Kiourkenidis, Georgios and Horn, Markus and Bollwein, Susanne and Bernhardt, Günther (2004) Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity. Stroke 35 (7), e338-e340.

xenografts Glioblastom

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg

Xenotransplantate

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg

Y Rezeptor

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg

Y1 agonist

Parker, S.L. and Parker, M. S. and Lundell, I. and Balasubramaniam, A. and Buschauer, Armin and Kane, J. K. and Yalcin, A. and Berglund, M. M. (2002) Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling. Regulatory Peptides 107 (1-3), pp. 49-62.

Y1 antagonist

Keller, Max and Teng, Shangjun and Bernhardt, Günther and Buschauer, Armin (2009) Bivalent argininamide-type neuropeptide Y Y1 antagonists do not support the hypothesis of receptor dimerisation. ChemMedChem 4 (10), pp. 1733-1745.

Parker, S.L. and Parker, M. S. and Lundell, I. and Balasubramaniam, A. and Buschauer, Armin and Kane, J. K. and Yalcin, A. and Berglund, M. M. (2002) Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling. Regulatory Peptides 107 (1-3), pp. 49-62.

Y1 receptor

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Y1 receptor antagonist

Keller, Max and Bernhardt, Günther and Buschauer, Armin (2011) [3H]UR-MK136 - a highly potent and selective radioligand for neuropeptide Y Y1 receptors. ChemMedChem 6 (9), pp. 1566-1571.

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Weiss, Stefan and Keller, Max and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), pp. 9858-9866.

Y1 Rezeptor

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Y1-Rezeptorantagonist

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. PhD, Universität Regensburg

Y1R antagonism

Keller, Max and Erdmann, Daniela and Teng, Shangjun and Pop, Nathalie and Pluym, Nikola and Bernhardt, Günther and Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), pp. 2859-2878.

Y1R binding

Keller, Max and Erdmann, Daniela and Teng, Shangjun and Pop, Nathalie and Pluym, Nikola and Bernhardt, Günther and Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), pp. 2859-2878.

Y2 receptor

Pluym, Nikola and Brennauer, Albert and Keller, Max and Ziemek, Ralf and Pop, Nathalie and Bernhardt, Günther and Buschauer, Armin (2011) Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists. ChemMedChem 6 (9), pp. 1727-1738.

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Ziemek, Ralf and Brennauer, Albert and Schneider, Erich and Cabrele, Chiara and Beck-Sickinger, Annette G. and Bernhardt, Günther and Buschauer, Armin (2006) Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y(2) receptor ligands. European Journal of Pharmacology 551 (1-3), pp. 10-8.

Y2 receptor antagonists

Pluym, Nikola (2011) Application of the guanidine–acylguanidine bioisosteric approach to NPY Y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools. PhD, Universität Regensburg

Y2 Rezeptor

Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg

Zelldifferenzierung

Colombo, Noemi (2007) Synthesis and conformational analysis of polypeptides related to the inhibitor of the DNA binding and cell differentiation Id2. PhD, Universität Regensburg

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

Zirkulardichroismus

Kiewitz, Sebastian Donatus (2007) Structural investigations of the Id helix-loop-helix dimerization domain. PhD, Universität Regensburg

Zymography

Oettl, Martin and Hoechstetter, Julia and Asen, Iris and Bernhardt, Günther and Buschauer, Armin (2003) Comparative characterization of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae in pharmaceutical preparations. European Journal of Pharmaceutical Sciences 18 (3-4), pp. 267-277.

Östrogene

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Östrogenrezeptor

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg

β2-adrenergic receptor

Brunskole, Irena (2011) Molecular and cellular analysis of aminergic G protein-coupled receptors: histamine H2, H4 and β2-adrenergic receptors, a scientific paradigm. PhD, Universität Regensburg

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